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EC number: 236-102-9 | CAS number: 13162-05-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no toxicokinetic studies available with N-Vinylformamide (VFA). Therefore, the following toxicokinetic assessment is based on the available information on physico-chemical parameters and results from other toxicity studies with VFA:
VFA is a liquid with a vapour pressure of 0.21 hPa at 20°C, has a molecular weight of 71.08 g/mol and a log Pow of -0.11 at 24°C.
Acute oral toxicity studies in rats provide evidence for systemic availability of VFA by the oral route (based on the observed clinical symptoms and the LD50 of > 1000 < 2000 mg/kg). In an acute dermal toxicity study in rabbits no signs of systemic toxicity of VFA were observed. Therefore, dermal absorption of VFA is expected to be rather low.
Results from the available repeated dose inhalation toxicity study in rats indicate systemic availability of VFA by this exposure route. In this study, the liver was the main target organ of systemic toxicity, but the kidney also represented a target organ at the highest concentration indicative for distribution of VFA to these organs.
The results from several in vitro genotoxicity studies with and without metabolic activation indicate that no reactive metabolite was formed after the addition of rat liver S9 mix.
Based on the log Pow of -0.11 VFA is expected to be not bioaccumulative. VFA is not stable in water and is expected to slowly hydrolyse at neutral pH to acetaldehyde and formamide.
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