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EC number: 475-900-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17-18 Jan. 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately characterised with its purity. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- March 23, 2006
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Directive 92/69/EEC
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from 2007-05-16
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 302 Pa
- Conclusions:
- Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), < 500 Pa).
- Executive summary:
The vapour pressure of the test substance was measured, under GLP, according to OECD 104 / EU A.4 guidelines, static method. Two runs were performed, with 12 measurements recorded between 45 and 100°C. The linear regression log VP = f(T) was derived, and vapour pressure at 20°C was extrapolated from the equation as 302 Pa.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 30 May - 28 June 2005
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. However, the test item identification is incomplete (unspecified cis-trans isomery, therefore identified under the generic CAS 17129-06-5). Therefore validation applies with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Directive 92/69/EEC
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from 2004-12-22
- Type of method:
- static method
- Temp.:
- 20 °C
- Vapour pressure:
- 265 Pa
- Executive summary:
The vapour pressure of the test substance was measured, under GLP, according to EU A.4 guideline, static method. One run was performed, with 5 measurements recorded between 30 and 50°C. The linear regression log VP = f(T) was derived, and vapour pressure at 20°C was extrapolated from the equation as 265 Pa.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 29 Aug. to 03 Sept. 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. However, the method used was not suitable for the magnitude of order of the vapour pressure of the test substance, according to guideline recommendations. But internal validation was extended to cover actual measurements. The substance is adequately characterised with its purity.Therefore validation applies with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- March 23, 2006
- Deviations:
- yes
- Remarks:
- recommended measuring range
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Directive 92/69/EEC
- Deviations:
- yes
- Remarks:
- recommended measuring range
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate from 2007-05-16
- Type of method:
- effusion method: isothermal thermogravimetry
- Temp.:
- 20 °C
- Vapour pressure:
- 465 Pa
- Executive summary:
The vapour pressure of the test substance was measured, under GLP, according to OECD 104 / EU A.4 guidelines, isothermal thermogravimetric method. The system was calibrated with seven reference substances, with VP between 1 .33 E-8 and 2.34 E+3 Pa at 20°C, as a linear regression. Three measurements were recorded at 20°C. The vapour pressure was interpolated from the equation as 465 Pa.
Referenceopen allclose all
Two series of 12 values were recorded (detailed results in experimental report).
The test substance was considered to show ideal behaviour. Using the linear relationship between 1/T and log VP, the vapour pressure at 20°C was determined by regression analysis. The curves were derived by using a least squares method to calculate a straight line that best fits the measured data (Clapeyron).
The coefficient of correlation (r) was > 0.99.
Extrapolation of the curve of the test substance to 20°C was 302 Pa.
Temperature (°C) | 30.7 | 37.1 | 42.2 | 46.1 | 50.5 |
Vapour pressure after corrections (Pa) | 569.8 | 842.1 | 1144.8 | 1568.0 | 1951.3 |
The corrected vapour pressure are plotted in a Clausius-Clapeyron plot. Regression through all data points yields:
log VP [Pa] = -6.2325 * 1/T*1000 (K) + 26.84
R2 = 0.9974
Extrapolation using this regression function yields an estimated vapour pressure of 265 Pa at 20°C and 379 Pa at 25°C.
Reference substances
Regression curve: log P,20 = 1.12 x log V,20 + 4.86 (r=0.997, n=14)
where:
P,20: vapour pressure at 20°C (Pa)
V,20: evaporation rate at 20°C (g/cm2/h)
Test substance
Experiment No. (at 20°C) |
Weight loss (µg/min) |
V,20 (g/cm2/h) |
log P,20 |
1 |
135.3 |
1.62 E-2 |
-1.79 |
2 |
130.6 |
1.56 E-2 |
-1.81 |
3 |
131.5 |
1.57 E-2 |
-1.80 |
Average log P,20 | -1.80 |
Fitting the average log P,20 value in the regression curve, a vapour pressure of 4.65 E2 Pa was obtained.
Description of key information
Low volatility at ambient temperature.
Key value for chemical safety assessment
- Vapour pressure:
- 302 Pa
- at the temperature of:
- 20 °C
Additional information
Three experimental studies are available; all were conducted according to OECD/EU guideline and GLP, and give quite consistent results:
- The static method, presented in Notox 2008 report, was considered to be the most suitable, considering the magnitude of order measured, and extrapolation from the working range was limited. Therefore it was considered as fully reliable, key study, and the result of 302 Pa at 20°C is retained as key data.
- In TNO 2005 report, the static method was also used, but the study was assigned lower reliability, due to incomplete test item identification (i.e. unspecified cis-trans isomery). The working temperature range was also smaller than above, so considered of lower quality for the regression, though extrapolation was even closer. Thus it is included as supporting data. The result (265 Pa at 20°C) is very consistent with the key value.
- An effusion method was used in Notox 2007 report, which is not recommended to measure vapour pressures above 1 Pa. However, the laboratory obtained reliable results for more volatile reference substances. Moreover, measurement was conducted for a single temperature, which is a deviation from the guideline, but no extrapolation was needed then. Finally, the result for the test item, 465 Pa at 20°C, is not that far from above, so this study was also included as supporting data.
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