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Diss Factsheets
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EC number: 216-653-1 | CAS number: 1634-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Three studies of acute toxicity to earthworms are available: each includes testing exposure by contact with wetted filter paper and exposure via soil. The lowest EC50 value arising from these studies is that reported by Lee, Yoon and An (2015) for Perionyx excavatus in artificial soil (made with 10% peat moss having a 95% organic matter content): 72h EC50 = 826 mg MTBE/kg dry soil.
Three studies of short-term toxicity to higher plants are available: unfortunately two monitored seed germination and post-emergence growth over only 5 days, much shorter than the relevant OECD test guideline requires and neither study is considered reliable for use in assessment. (Although Dodd and Addison, 2010 reported 5-day EC50s for parameters of lettuce seedling germination and growth of 81-127 mg MTBE/kg dry soil, this was not supported by a study of An and Lee, 2008 where for 7 different food crop species, including 3 dicotyledonous species listed alongside lettuce in Annex 2 of the OECD 208 guideline, the lowest 5-day LC50 was considerably higher at 680 mg/kg dry soil). The third study examined effects of MTBE exposure on the growth of white corn, Zea mays L (Ismail et al., 2012), but its report gives insufficient information to transcribe the dose information into a dose per unit of soil.
One reliable study of long-term toxicity to terrestrial organisms is available: Dodd and Addison, 2010 studied survival and reproduction in Collembola species (springtails). For the most sensitive of 3 species tested, Onychiurus folsomi, a 35-day NOEC for reproduction of 156 mg/kg dry soil was determined in sandy loam soil with a low organic matter content (1.14%): all other NOECs (across the 3 springtail species in OECD 207 artificial soil, plus O. folsomi tested also in sandy loam and silt loam) were within the range 305-620 mg MTBE/kg dry soil.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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