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Diss Factsheets
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EC number: 215-236-1 | CAS number: 1314-56-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
refer to "Justification for classification"
Short description of key information:
Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local (genotoxic) effects due to the strong corrosivity of the generated phosphoric acid. Therefore, a read across to the data generated with Phosphoric acid is justified.
Mutagenic activity of Phosphoric acid was investigated in two bacterial reverse mutation assays (Ames test; test strains used: S. typhimurium TA97, TA 98, TA 100, TA 104, TA 1535, TA 1537 and E. coli WP2 uvr A), and in an in vitro chromosome aberration study in mammalian cells (Chinese Hamster Lung). Negative results were obtained in all tests with and without metabolic activation.
Furthermore, no genotoxcity was observed in a gene mutation study (HPRT test) with Diphosphorus pentaoxide performed in V79 Chinese hamster lung fibroblasts.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Diphosphorus pentaoxide is a hygroscopic solid which forms with moisture/water an aqueous solution of phosphorus oxyacids (primary hydrolysis) that are subject to further (secondary) hydrolysis to the end product phosphoric acid, H3PO4. The exposure to Diphosphorus pentaoxide under physiological conditions (aqueous system) will principally lead to local (genotoxic) effects due to the strong corrosivity of the generated phosphoric acid. Therefore, a read across to the data generated with Phosphoric acid is justified.
Phosphoric acid did not show chromosome aberrations regardless of application of metabolic activiation in a chromosome aberration study using Chinese hamster lung cells (CHL/IU). Phosphoric acid was also considered to be non-genotoxic in the bacterial reverse mutation test.
Furthermore, no genotoxcity was observed in a gene mutation study (HPRT test) with Diphosphorus pentaoxide performed in V79 Chinese hamster lung fibroblasts.
It can be concluded from the data available that mutagenicity and genotoxicity are not caused by Phosphoric acid and also by Diphosphorus pentaoxide (which hydrolyses in aqueous solutions completely to Phosphoric acid). Therefore, a classification for this endpoint is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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