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Diss Factsheets
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EC number: 204-211-0 | CAS number: 117-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Due to several shortcomings, this study is not adequate for hasard assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Electron microscopical and cytochemical observations of the mouse liver following the Administration of phthalate ester (DOP).
- Author:
- Watari N, Kanai M, Torizawa K
- Year:
- 1 978
- Bibliographic source:
- J. Clin. Electron Microscopy 11, 103-120
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2-ethylhexyl) phthalate
- EC Number:
- 204-211-0
- EC Name:
- Bis(2-ethylhexyl) phthalate
- Cas Number:
- 117-81-7
- Molecular formula:
- C24H38O4
- IUPAC Name:
- 1,2-bis(2-ethylhexyl) benzene-1,2-dicarboxylate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: DDY
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- olive oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.2 ml of a 10, 30, 50, or 100% solution
Basis:
- No. of animals per sex per dose:
- 3 animals per dose group in a first experiment and 2 per group in a second
- Control animals:
- yes, concurrent vehicle
Examinations
- Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes
Results and discussion
Results of examinations
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- Macroscopically, the liver was greatly enlarged, lacked elasticity, and had a dark brown colour. Inflammatory signs were observed in the peritoneum in the two highest dose groups.
Structural alterations of the liver tissues were observed by light and electron microscopy and by cytochemistry in all dosed groups. In hepatic cells, the nuclei were atrophied and frequently contained fat droplets. The smooth endoplasmic reticulum was proliferated and vesiculated.
Mitochondria were decreased in size and some were degenerated. An unusual proliferation of the microbodies and their morphological alterations were found.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
DEHP (purity not specified) was percutaneously administered to DDY-mice (3 animals per dose group in a first experiment and 2 per group in a second) as daily doses of 0.2 ml of a 10, 30, 50, or 100% solution in olive oil for one month. Macroscopically, the liver was greatly enlarged, lacked elasticity, and had a dark brown colour. Inflammatory signs were observed in the peritoneum in the two highest dose groups. Structural alterations of the liver tissues were observed by light and electron microscopy and by cytochemistry in all dosed groups. In hepatic cells, the nuclei were atrophied and frequently contained fat droplets. The smooth endoplasmic reticulum was proliferated and vesiculated. Mitochondria were decreased in size and some were degenerated. An unusual proliferation of the microbodies and their morphological alterations were found.
The authors concluded that the results showed that DEHP is absorbed percutaneously and accumulates in the mouse liver resulting in damage to the cellular organelles.
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