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Diss Factsheets
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EC number: 202-679-0 | CAS number: 98-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence Assessment
The substance has shown to be readily biodegradable in one test (OECD 301 A) and in two other tests failed to pass the 10 day window criterion, although showing a significant aerobic biodegradation of 60% within 28 days (OECD 301B-test, OECD 301F-test). However, clearly the substance is biodegradable and therefore does not fulfill the criteria for persistence in the environment. A modified MITI-test suggested that ptBP could not be considered as inherently biodegradable but this result may be attributable to the inhibitory concentration of ptBP used resulting in a long lag phase under the test conditions. Hydrolysis is not expected under relevant environmental conditions (no experimental data) and from the structure of the substance it can be deduced that it does not undergo abiotic degradation through hydrolysis. According to Regulation (EC) No 1907/2006 (REACH) ANNEX XIII and the Guidance on information requirements and chemical safety assessment, Chapter R.11 (PBT Assessment, May 2008), the substance does not fulfill the screening criterion “persistent (P)” and “very persistent (vP)” as within an OECD 301A study the substance showed to be degradable at a rate of 98% determined by DOC-removal within 28 days. The substance can be considered as readily biodegradable but failing the 10-day window.
Bioaccumulation Assessment
According to Annex XIII of Regulation (EC) No 1907/2006 and to the Guidance on information requirements and chemical safety assessment Chapter R.11 (PBT Assessment, May 2008), a substance does not fulfill the criterion “bioaccumulative (B)” or “very bioaccumulative (vB)” if the BCF is below 2000 or 5000 respectively or the log Kow is below 4.5. The bio concentration factor of p-tert. butyl phenol was determined to be 20-43 upon exposure of 40 mg/l and 38-88 upon exposure to 4 µg/l as determined by the Ministry of Trade and Industry (MITI) in Japan according to an OECD 305C guideline test. The log POW value determined by HPLC method (OECD 117) was found to be 3 (at 23 °C and pH of 5.7). Consequently, both the logPOW as well as the BCF values determined for para tert.butyl phenol were found to be well below the screening criteria as defined in Annex XIII of the REACH regulation and a potential for bioaccumulation is not expected. According to Guidance on information requirements and chemical safety assessment (May 2008), Chapter R.11, Figure 11-2: Integrated testing strategy for B-assessment, no further testing is required to conclude on the bioaccumulation criterion.
Toxicity Assessment
The substance is classified as toxic for reproduction (category 2) according to Regulation (EC) NO. 1272/2008 and classified as Cat. 3
(developmental effects) as set out in Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.