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EC number: 287-477-0 | CAS number: 85535-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Low sensitivity method with widely varying limits of detection, but data considered acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
- Type of study / information:
- Concentrations of MCCPs detected in human and bovine milk-fat
- Endpoint addressed:
- basic toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Concentrations of MCCPs in samples of butter/cow milk-fat and randomly selected samples of human breast milk determined by gas-chromatography/high-resolution mass spectrometry (GC-HRMS).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Alkanes, C14-17, chloro
- EC Number:
- 287-477-0
- EC Name:
- Alkanes, C14-17, chloro
- Cas Number:
- 85535-85-9
- Molecular formula:
- Substance is a range of chlorinated isomers of C14 to C17 paraffin
- IUPAC Name:
- Alkanes, C14-17, chloro
- Details on test material:
- - Name of test material (as cited in study report): medium-chain chlorinated paraffins (MCCPs)
- Substance type: technical product
- Physical state: no data
- Analytical purity: no data
- Composition of test material, percentage of components: C14-17 chlorinated paraffins
- Impurities: no data
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- Human milk samples were collected anonymously from 22 women in maternity units (8 from Lancaster and 14 from London) and immediately frozen. Butter samples were bought in 7 regions of Europe and one milk sample obtained from Lancaster. All samples were kept below -20oC until analysed. Milk fat was separated from samples by centrifugation, dissolved in hexane and lipids removed by chromatography. Chloinated paraffins were recovered by solvent extraction on an activated Florisil column (15:85 dichloromethane: hexane followed by 1:1 dichloromethane: hexane) and analysed by gas-chromatography/mass spectrometry. [13C8]mirex was used as internal standard for the analysis.
- Exposure assessment:
- not specified
- Details on exposure:
- no data
Results and discussion
- Results:
- Detectable levels of MCCPs were found in cow milk-fat (63 ng/g) and in butter samples from Denmark (11 ng/g), Ireland (52 ng/g) and Wales (8.8 ng/g). Detectable levels of MCCPs were found in only one human milk sample (61 ng/g) from London.
Any other information on results incl. tables
Detection limits in human milk-fat samples varied with sample size, but ranged from 16 to 740 ng/g fat (mean level of 100 ng/g fat) and from 8 to 9.2 ng/g in butter.
Applicant's summary and conclusion
- Conclusions:
- Only one out of 22 human breast milk samples analysed contained detectable levels of MCCPs (61 ng/g fat). Bovine milk/butter fat from England, Wales, Ireland and Denmark had detectable levels of MCCPs of 63, 8.8, 52 and 11 ng/g fat respectively; those from France, Germany and Italy were below detection limits.
- Executive summary:
The concentration of MCCPs in human and bovine milk-fat has been determined by gas chromatography/high resolution mass spectrometry. Milk samples from 22 apparently randomly selected women (8 from Lancaster and 14 from London) and bovine milk/butter samples from England and 7 other European regions were analysed.
Detection limits for individual samples were determined and ranged from 16 to 740 ng/g for human milk-fat (with a mean level of 100 ng/g fat) and 8 to 9.3 ng/g for bovine butter-fat. Only one human milk sample had a detectable level of mPCAs (61 ng/g). The bovine milk-fat sample from Lancaster had an mPCAs concentration of 63 ng/g and butter samples from Ireland, Denmark and Wales had levels of 52, 11 and 8.8 ng/g, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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