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EC number: 209-529-3 | CAS number: 584-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication report which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats
- Author:
- Shibata M-A, Tamano S, Kurata Y, Hagiwara A, Fukushima S
- Year:
- 1 989
- Bibliographic source:
- Food Chem. Toxic. 27(6): 403-413
Materials and methods
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Potassium carbonate
- EC Number:
- 209-529-3
- EC Name:
- Potassium carbonate
- Cas Number:
- 584-08-7
- Molecular formula:
- CH2O3.2K
- IUPAC Name:
- dipotassium carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- They were housed in plastic cages on hard-wood chip bedding in an environmentally controlled room, maintained at 22 +/- 2 °C and artificially illuminated for 12 hours each day.
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: powdered basal diet
- Details on exposure:
- Powdered basal diet (Oriental M, Oriental Yeast Co, Tokyo, japan) suppemented with 3 % Potassium carbonate.
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Changes in urinary parameters (electrolyte levels and pH) and DNA synthesis and the morphology of the bladder epithelium were investigated in male rats that were fed for 4 or 8 weeks on diets containing various
Na, K, Mg or Ca carbonate salts (3 %) with or without L-ascorbic acid (5 %). Beside increases in urinary pH, sodium and potassium and decreases of chloride, DNA synthesis in the bladder epithelium was increased in groups given sodium bicarbonate, potassium carbonate with or without L-ascorbic acid.
Furthermore some morphological alterations in the bladder epithelium were detected by light microscopy hyperplasia consisting of diffuse thickening of the epithelium with four to eight layers of the epithelial cells addjected) and scanning electron microscopy (pleomorphic or short, uniform microvilli and ropy or leafy microridges). Administration of ascorbic acid in combination with the salts induced levels of change greater than those with the salts alone.
After administration of ascorbic acid or NH4C alone, resulting in a drop of urinary pH, those effects on the bladder epithelium were not observed.
Therefore, the study authors suggest that the degree of DNA synthesis and/or morphological alteration in the rat-bladder epithelium after treatment with various bases may depend on changes in urinary concentrations of Na- or K-ions and/or pH, and the presence of ascorbic acid in the urine.
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