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EC number: 203-234-3 | CAS number: 104-76-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated and different from today standard methods
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human skin sensitization test using the maximization method of Kligman (ref.2)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexan-1-ol
- EC Number:
- 203-234-3
- EC Name:
- 2-ethylhexan-1-ol
- Cas Number:
- 104-76-7
- Molecular formula:
- C8H18O
- IUPAC Name:
- 2-ethylhexan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2 ethyl hexanol
- no further information on test substance
Constituent 1
Method
- Type of population:
- other: healthy innate male volunteers
- Subjects:
- 35 test subjects were screened, 29 volunteers completed the study
- Controls:
- not required
- Route of administration:
- dermal
- Details on study design:
- RANGE FINDING TESTS: irritation effects of test substance were tested in a pilot study. Test substance was applied under occlusive conditions to the back of at least 10 test subjects for 24 h and the reaction was rated. If no irritation was observed, the induction sites were pretreated for 24 h with 1.0 mL of a 5% aqueous sodium lauryl sulfate solution on a Webril patch.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 5; before the first application, the induction site was pretreated under occlusive conditions for 24 h with 1.0 mL of a 5% aqueous sodium lauryl sulfate solution on a 1.5 x 1.5 inch Webril patch
- Exposure period: 15 days follwed by an 10 to 14 day rest period
- Test groups: 1 test group only
- Control group: no
- Site: inside of forearms
- Frequency of applications: exposure periods of 48 h were follwed by a rest period of 24 h
- Duration: 72 h
- Volume applied: 1.0 mL of test substance
- Concentration 4% in petrolatum
B. CHALLENGE EXPOSURE
- No. of exposures: 1; before the challenge exposure with test substance, the application site is pretreated under occlusive conditions for 30 minuteswith 0.4 mL of a 10% aqueous sodium lauryl sulfate solution on a Webril patch
- Day(s) of challenge: 1
- Exposure period: 48 h
- Test groups: 1 test group only
- Control group: no
- Site: on the back of test subjects
- Volume applied: 0.4 mL
- Concentration 4% in petrolatum
- Evaluation (hr after challenge): immediatly after removal of the patch and after 2 days
Results and discussion
- Results of examinations:
- 2-Ethylhexanol did not produce any reactions that were considered irritant or allergic in the 29 human subjects tested. Under the conditions of the test used, 2-ethanol was not sensitizing.
Applicant's summary and conclusion
- Conclusions:
- 2-Ethylhexanol did not produce any reactions that were considered irritant or allergic in the 29 human subjects tested. Under the conditions of the test used, 2-ethanol was not sensitizing.
- Executive summary:
In a dermal sensitization study, the sensitizing potential of 2-ethylhexanol was tested on 29 male human volunteers using the maximization method of Kligman. There was one test group and no controls. For induction, 1.0 mL of the test substance was applied for 48 h under occlusive conditions in 5 alternating repetitions (48 hours occlusive exposure, 24 hours exposure free period). After a rest period of 10 to 14 days, challenge exposure consisted of a single occlusive application of 0.4 mL of 2-ethylhexanol for 48 h. Immediately after removal of the patch and after 48 h, skin reactions were recorded. None of the tested subjects showed any signs of irritation or sensitisation.
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