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Diss Factsheets
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EC number: 249-079-5 | CAS number: 28553-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
DINP has been tested with multiple aquatic organisms in acute and chronic studies. The results demonstrate that DINP does not cause any adverse effects within the limits of water solubility. In addition the test conducted with amphibia (Moor frog) also did demonstrate the absence of adverse effects on the development of the larvae exposed up to 858 mg/kg sediment (d.w.).
DINP does not produce acute or chronic aquatic toxicity in fish, invertebrates, and algae. It has also been shown not to adversely impact the population parameters evaluated in a multi-generation study with a fish species, demonstrating that DINP does not have the potential to cause endocrine disruption in the aquatic environment. The absence of toxicity demonstrated by DINP is, at least in part, due to its low water solubility, resulting in low exposure potential, as well as the ability of organisms to metabolize DINP at a rate that prevents a critical body burden from being reached. The data for DINP show that it is not toxic at its maximally attainable water solubility level, which varies dependent on the conditions of study. Since DINP does not cause acute or chronic aquatic toxic effects at the limits of water solubility, it is not possible to derive NOEC or PNEC values needed for quantitative risk assessment. However, it is possible to qualitatively conclude based on low solubility and the results of acute and chronic aquatic toxicity tests that DINP does not pose an unacceptable risk to the aquatic compartment.
LITERATURE RELATED TO DINP ENDOCRINE DISRUPTION POTENTIAL IN AQUATIC ORGANISMS PUBLISHED BETWEEN 2014 TO 2022:
A literature search allowed identifying a number of papers conducting tests of potential interest regarding the ecotoxicological effects of DINP. However, after assessment it was concluded that all of them present significant reporting omissions or methodological flaws, rendering them not useful for regulatory assessment (Klimisch 3 and 4). For transparency, the RSS for those papers are included in this update.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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