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Diss Factsheets
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EC number: 292-122-8 | CAS number: 90552-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a well-conducted OECD combined repeated dose and reproductive/developmental toxicity screening test (OECD TG 422) by oral gavage in rats no toxicity occurred up to the highest administered dose of 1000 mg/kg/day. The NOAEL was determined to 1000 mg/kg/day.
With regard to the low repeated dose oral toxicity and the characteristics of skin penetration and metabolism in the skin, the repeated dose dermal toxicity can be considered as low. The inhalation route is not of relevance due to the very low vapour pressure of the substances. Taken as a whole there are sufficient data available for the long-chain alkyl methacrylate esters for assessment purposes so for the sake of animal welfare it is not proposed to conduct further repeated dose studies.
Key value for chemical safety assessment
Additional information
In a well-conducted OECD combined repeated dose and reproductive/developmental toxicity screening test (OECD TG 422) by oral gavage in rats, no toxicity occurred up to the highest administered dose of 1000 mg/kg/day.
The NOAEL for the repeated dose toxicity by oral gavage was determined to 1000 mg/kg/day.
Supporting information: In an OECD guideline 408 90-day gavage study in Wistar rats with the C8 Ester 2-ethylhexyl methacrylate, including a recovery period of 28 days, signs of general systemic toxicity occurred in male as well as female rats at 360 mg/kg bw/day. The NOAEL was120 mg/kg bw/day in males and females.
There are no data available for repeated dose exposure by the dermal or inhalation route. With regard to the low repeated dose oral toxicity and the characteristics of skin penetration and metabolism in the skin, the repeated dose dermal toxicity can be considered as low. This skin absorption study indicates that the total amount of the ester dodecyl methacrylate that was absorbed during the time of exposure was 0.7 % (rat epidermis) and 0.26 % (rat whole skin) over 24 hours, respectively. Thus, toxic effects via the dermal route are unlikely. The inhalation route is not of relevance due to the very low vapour pressure of the substances. Taken as a whole there are sufficient data available for the long-chain alkyl methacrylate esters for assessment purposes so for the sake of animal welfare it is not proposed to conduct further repeated dose studies.
Justification for classification or non-classification
EU classification according to Annex VI of the Directive 67/548/EEC:
- No classification required.
GHS classification according to Annex I 1272/2008 CLP (EU GHS):
- No classification required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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