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Diss Factsheets
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EC number: 202-409-1 | CAS number: 95-31-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- assumption of toxicokinetic
- Type of information:
- other: assumption of toxicokinetic
- Adequacy of study:
- supporting study
- Reliability:
- other: assumption of toxicokinetic
- Rationale for reliability incl. deficiencies:
- other: assumption of toxicokinetic
Data source
Reference
- Reference Type:
- other: OECD SIDS
- Title:
- SIDS Initial Assessment Report, N-tert-butylbenzothiazole-2-sulphenamide, CAS No 95-31-8
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- Assumption of toxicokinetics.
- GLP compliance:
- no
Test material
- Reference substance name:
- N-tert-butylbenzothiazole-2-sulphenamide
- EC Number:
- 202-409-1
- EC Name:
- N-tert-butylbenzothiazole-2-sulphenamide
- Cas Number:
- 95-31-8
- Molecular formula:
- C11H14N2S2
- IUPAC Name:
- N-(1,3-benzothiazol-2-ylsulfanyl)-2-methylpropan-2-amine
Constituent 1
Results and discussion
Any other information on results incl. tables
There are no study data available for the toxicokinetic of the test substance TBBS. However, considering the experiences with TBBS in acute and repeated dose toxicity studies, a characterization of TBBS toxicokinetics can be conducted as discussed in the OECD SIDS 2003:
"The test material is a solid. No details of particle size distribution have been given, but a repeated-dose toxicity study using the inhalation route indicates some systemic toxicity. The vapour pressure value for the test material is low (< 0.21 x 10-5 hPa at 25 °C, OECD SIDS 2003).
The test material is expected to hydrolyse readily at pH values below 9. This suggests that systemic exposure to degradants can be expected, particularly following oral ingestion. The log oil/water partition coefficient value is moderate (log Pow 3.9 at room temperature), which suggests that test material passage across biological membranes is possible.
Absorption
The results of the acute and repeated dose oral toxicity studies in the rat suggest that the test material is absorbed from the gastro-intestinal tract. Systemic effects are observed, particularly with cumulative exposure. Because of the rapid hydrolysis of the test material, it is likely that toxicity is a result of exposure to degradants. The test material has low water solubility (0.345 mg/l at 20°C, OECD SIDS 2003) which may restrict absorption of the parent molecule but hydrolysis may enhance water solubility. The moderate log oil/water partition coefficient of the parent molecule will allow passage across the biological membranes of the gastro-intestinal tract. The results of the acute dermal toxicity studies in the rabbit show that the test material is not more toxic by this route. The results of human patch tests and a sensitisation study in the guinea pig show that the test material (or a product of hydrolysis, mercaptobenzothiazole) is absorbed through the skin. The results of a repeat dose study in the rat by inhalation exposure shows that the test material (or a hydrolysis product) can be absorbed by inhalation.
Distribution
The results of the repeat dose oral and inhalation studies in the rat suggest some systemic distribution. Following oral ingestion it is likely that the test material (or hydrolysis products) is distributed via the porta circulation system. The positive sensitisation response suggests that the hydrolysis products may bind to circulatory proteins. The moderate log oil/water partition coefficient value suggests that the test material could potentially accumulate in body fat. Because the test material hydrolyses, it is likely to result in products with a lower partition coefficient value.
Metabolism
The widespread distribution throughout tissues such as the gastro-intestinal tract, and the tendency of the test material to undergo hydrolysis suggest that initial metabolism of the material will be widespread and non-specific. The results of the repeat dose oral and inhalation studies in the rat do show microscopic changes in the liver. This may be indicative of further metabolism of hydrolysis products. The results of in vitro mammalian cell genotoxicity studies show that a positive genotoxic effect is seen, but only in the presence of S9 metabolising system. This indicates that metabolism of the parent test material or a hydrolysis product is required to produce a positive response. The results of separate reproduction/developmental toxicity studies in the rat with the test material and an analogue (either N-cyclohexylbenzothiazole-2-sulfenamide or N, N-dicyclohexylbenzothiazole-2-sulfenamide) show differences in developmental toxicity. If, as expected, the analogues undergo hydrolysis/metabolism as does the test material, it may be suggested that the profile of the metabolites may be significant in the toxicity of the product.
Excretion
The results of some of the repeated dose oral toxicity studies show changes in the kidneys of rats. This suggests that urinary excretion is a significant route for removal of test material" (OECD SIDS 2003).
Applicant's summary and conclusion
- Executive summary:
Assumption of toxicokinetic
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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