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Diss Factsheets
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EC number: 203-400-5 | CAS number: 106-46-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No particle size of Paradichlorobenzene mentioned.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to vapour produced by passing air through the test substance; control group was included. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination.
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Paradichlorobenzene Lot 08146-P (A)
- IUPAC Name:
- Paradichlorobenzene Lot 08146-P (A)
- Reference substance name:
- 1,4-dichlorobenzene
- EC Number:
- 203-400-5
- EC Name:
- 1,4-dichlorobenzene
- Cas Number:
- 106-46-7
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,4-dichlorobenzene
- Test material form:
- solid: crystalline
- Details on test material:
- p-dichlorobenzene, lot: 08146-P
content 99.9 %
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 10 male rats at the age of 6 weeks.
10 female rats at the age of 8 weeks.
These ages of rats were selected so that the males and females were at similar bodyweight (ca. 200g).
Housing : in groups of 5
acclimisation pereiod: 5 days
room temperature: 21-22 °C
relative humidity: 48-50 %
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- 5 male and 5 female rats were exposed continously for 4 hours to a test atmosphere containing vapour from the test substance.
another 5 male and 5 female rats acting as a control received clean air only for 4 hours. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- control group and a test group exposed to 5,07 mg/l atmosphere concentration of Paradichlorobenzene vapour.
- No. of animals per sex per dose:
- 5 male and 5 female rats.
- Control animals:
- yes
- Details on study design:
- The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to vapour produced by passing air through the test substance; control group was included. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination.
- Statistics:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.07 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: unspecific reactions to exposure, recovery within 1 day, no animal died
- Mortality:
- There were no deaths during the study.
- Clinical signs:
- other: Signs during exposure: closing of eyes, wetness around the mouth, fluid discharge from the mouth, exagerated respiratory movements. Signs during observation period: increased respiration rate, wet fur around snout and jaws, yellow staining around the urog
- Body weight:
- small losses in body weight were observed in all rats exposed to paradichlorbenzene for 1 day following exposure. Subsequently weight gain was
similar to that of the control rats. - Gross pathology:
- The lung weight to body weight ratio for all rats was within the normal limit. ther were no abnormalities in th rats.
Any other information on results incl. tables
There were no deaths following an acute inhalation toxicity 4- hour exposure to vapour with paradichlorobenzene.
Applicant's summary and conclusion
- Executive summary:
The acute inhalation toxicity of p-dichlorobenzene was assessed by exposing 10 rats for a period of 4 hours to 5070 mg/m³ vapour produced by passing air through the test substance; control group was included. The test precedure was equivalent to OECD TG 403 and performed under GLP condions. After termination of the observation period of 14 days the animals were sacrificed and subjected to macroscopic examination. Immediately following exposure an increased respiration rate was seen. This and other minor signs disappeared by the day following exposure and subsequently all rats were normal. No animal died.
The LC50 of paradichlorobenzene in rat was found to be greater than 5,07 mg/l air (5070 mg/m³ air).
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