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Diss Factsheets
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EC number: 219-291-2 | CAS number: 2403-88-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
There was one report from a study on skin sensitization in guinea pigs according to the method described by Magnusson and Kligman (Ciba GmbH Lampertheim, 1993). This study was identified as the key study because it was well conducted and used a current protocol [OECD TG 406]. In this in vivo study, 30 female and male guinea pigs were used (10 male and 10 female animals as test group, and 5 male and 5 female animals served as control group). During the induction procedure the test group was exposed to 1 % 2,2,6,6 -tetramethylpiperidin-4 -ol via intradermal injection and 50 % 2,2,6,6 -tetramethylpiperidin-4 -ol via topical application. The control group was exposed to vehicle only during this procedure. All animals were challenged with 30% 2,2,6,6 -tetramethylpiperidin-4 -ol and vehicle and all animals were rechallenged with 10% of the test substance and vehicle. At challenge, 9/16 (56%) positive responses were noted in the test group after 24 and 48 h and 7/10 (70%) positive response was noted in the control group following treatment with 50% 2,2,6,6 -tetramethylpiperidin-4 -ol after 24 and 48 h. At rechallenge, 5/16 (31%) and 11/16 (69%) positive responses were noted in the test group and 0/10 positive responses were noted in the control group following treatment with 10% 2,2,6,6 -tetramethylpiperidin-4 -ol after 24h and 48h.
In all animals of the test group clinical symptoms (hunched posture, piloerection, and sedation) were observed. Since initially symptoms were observed in all animals of the test group and with respect to the mortality recorded (two animals moribund, two animals found dead) treatment-relation cannot be fully excluded.
Conclusion: 2,2,6,6 -tetramethylpiperidin-4 -ol showed a moderate to strong grade of skin-sensitising (contact allergenic) potential
according to the grading of Magnusson and Kligman in albino guinea pigs.
Migrated from Short description of key information:
sensitising, CIBA,1993, GLP-OECD Guideline study
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Actually no data available.
Justification for classification or non-classification
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
Skin sensitisation:
The available experimental test data are reliable and suitable for the purpose of classification under Regulation (EC) No.1272/2008. As moderate to strong grade of skin-sensitising potential according to the grading of Magnussion and Kligman were observed, 2,2,6,6 -tetramethylpiperidin-4 -ol has to be classified as Category 1 A (H317).
Respiratory sensitisation
Actually, there are no data available for a classification regarding to this endpoint.
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