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Diss Factsheets
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EC number: 238-485-8 | CAS number: 14484-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, non-guideline study, available as unpublished report, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One group of 5 male and 5 female rats was exposed to 4.92 mg/L of the test substance for 1 hour, followed by an observation period of 14 days.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminum potassium fluoride
- EC Number:
- 262-153-1
- EC Name:
- Aluminum potassium fluoride
- Cas Number:
- 60304-36-1
- Details on test material:
- - Name of test compound: Nocolok 100 flux, 41105734
- Source: Hazleton Laboratories America, Inc.
- ABC test article Code Number: 12/84-867
- analytical purity not further specified in the report
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Crl:CD (SD) BR
- Source: Charles River Breeding Laboratories, Portage, MI.
- Housing: individually, cage size conformed to the standards specified in DHEW Publication (NIH) 78.23
- Diet: ad libitum, Purina Certified Rodent Chow 5002, ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): within the range specified in ABC SOP's
- Humidity (%): within the range specified in ABC SOP's
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Stainless steel and glass inhalation chamber
- Exposure chamber volume: 80
- Method of holding animals in test chamber: cage
- Source and rate of air: 21.1 l/min
- System of generating particulates/aerosols: The aerosol was generated by passing a stream of air through the test article contained in a dust shaker mechanism. The resulting air-dust mixture entered the top center of the inhalation chamber and exhausted at the bottom of the chamber. A stream of additional air was added to the chamber to achieve the desired concentration and to aid in test article dispersion
- Method of particle size determination: Delron cascade impactor, model no. DCI-6
- Treatment of exhaust air: Exhausted test atmosphere was diluted prior to release to the outside atmoshpere via an exhaust blower
- Temperature, humidity, pressure in air chamber: T: 72.3 F; RH: 40.0%; P: -0.10 inches of water
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetrical analysis
- Samples taken from breathing zone: yes
TEST ATMOSPHERE
- Particle size distribution: 99.8% of the weight of the particles is contributed by particles less than or equal to 10.0 µm
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): MMAD: 1.30 µm / GSD: 1.58 - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrical analysis
- Duration of exposure:
- 1 h
- Concentrations:
- 4.92 mg/L (gravimetric concentration); 87.2 mg/L (nominal concentration)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: During exposure: incidence of mortality and reactions displayed every 15 min. Observation period: twice daily mortality checks. Weighing: prior to exposure and on day 14
- Gross necropsy of survivors performed: yes, external surface and body orifices, cervical organs, thoracic organs, abdominal and pelvic organs, and the brain
Results and discussion
- Preliminary study:
- not performed
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4.92 mg/L air
- Exp. duration:
- 1 h
- Mortality:
- 1 male, 3 females
- Clinical signs:
- other: Irregular breathing, poor coat quality, yellow/brown stained fur, lethargy, crusty eye, crusty nose, and crusty muzzle
- Body weight:
- Mean (+/- SD) in grams. Males: day 0: 233.4 (15.9), day 14: 281.0 (28.1). Females: day 0 225.0 (24.9), day 14: 245.5 (30.4)
- Gross pathology:
- Abnormalities of the stomach (multifocal erosions, diffuse red brown discoloration of glandular mucosa), glandular stomach (mucosa smooth and discolored red brown), heart (diffusely pale, tan discoloration, mottling) and small intestine (dark contents) were observed in 2 males and 3 females.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.