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EC number: 500-094-8 | CAS number: 37208-53-0 1 - 6.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Although no carcinogenicity study is available, it is concluded that carcinogenicity is not an endpoint of concern. There is no evidence from the in vitro genotoxicity studies that 2,2',2''-Nitrilotriethanol, propoxylated is able to induce mutagenicity. Furthermore the available repeated dose toxicity study gives no evidence of serious or severe toxicity up to and including 1000 mg/kg (NOEAL= 1000 mg/kg) and no preneoplastic lesions were observed. Using the weight of evidence, it is concluded that carcinogenicity is not an endpoint of concern for 2,2',2''-Nitrilotriethanol, propoxylated and there is no trigger for a carcinogenicity study.
Additional information
No carcinogenicity study is available but there is information from a qualitative and quantitative understanding of the toxicological properties of the substance that a weight of evidence approach was used to decide on classification.
Proposals concerning long term repeated dose/carcinogenicity studies are set out in Illing and Barratt, (2009). Results can be 'read across', as permitted by Annex XI para 1.5, based on the justification in the reports from Paul Illing Consultancy Services Ltd and Marlin Consultancy (2007 and 2009) and on ECHA guidance. The anticipated result is that the substance is not carcinogenic. Thus, on animal welfare grounds this test should not be undertaken on 2,2',2''-nitrilotriethanol, propoxylated. For further details concerning the justification, consult Illing and Barratt, 2007 and 2009.
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