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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 212-741-9 | CAS number: 865-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- July 19, 2006
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium 2-methylpropan-2-olate
- EC Number:
- 212-741-9
- EC Name:
- Sodium 2-methylpropan-2-olate
- Cas Number:
- 865-48-5
- Molecular formula:
- C4H10O.Na
- IUPAC Name:
- sodium 2-methylpropan-2-olate
- Details on test material:
- - Name of test material (as cited in study report): Na-tert.-Butylat L (PRD 30153329)
- Analytical purity: 98.1g/100g (homogenous)
- Lot/batch No.: 35694816K0
- Stability under test conditions: stability under storage conditions was guaranteed by the sponsor
- pH-value: ca. 14 (undiluted test substance, moistened with water)
Constituent 1
Test animals
- Species:
- other: in vitro
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- MATERIAL AND TECHNICAL EQUIPMENT:
- Corrositex Kit containing reagents required for qualification and categorization screen, biobarrier matrix powder and diluent, membrane discs and vials containing the Chemical Detection System (InVitro International, Irvine, California)
Test system
- Type of coverage:
- other: not applicable
- Preparation of test site:
- other: not applicable
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Negative control: 10% Citric Acid, Positive Control: Sodium Hydroxide (solid)
- Amount / concentration applied:
- Qualification Screen:
100 mg
Categorization Screen:
100 mg to tube A and B each
Corrositex Assay:
350 mg - Duration of treatment / exposure:
- Following application of test substance onto the mebranes, time until break through of the substance is monitored (indicated by change in the Chemical Detection System).
- Observation period:
- up to 240 minutes, for substances determined into category 1 by Categorization screen
up to 60 minutes, for substances determined into category 2 by Categorization screen - Number of animals:
- not applicable
- Details on study design:
- TEST SUBSTANCE:
- 4 vials were used for the experiment
- first vials was observed for 3 minutes, if no color change was observed the remaining 3 were treated with test substance and time until break through of the substance was monitored and recorded
POSITIVE CONTROL
- one pellet of Sodium Hydroxide was applied on top of membrane and vial was monitored until break through occured
NEGATIVE CONTROL
- 500 uL of 10% citric acid were applied on top of membrane, vial was observed for 60 minutes, if no break through occured, evaluated as being non-corrosive
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: break through time
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 8 min 16 seconds. (migrated information)
In vivo
- Irritant / corrosive response data:
- Na-tert.-Butylat L showed a mean break through time of 8 minutes and 16 seconds.
- Other effects:
- not applicable
Any other information on results incl. tables
Table2: Findings
Break Through Time [min:s] |
|||||
vial 1 | vial2 | vial 3 | vial 4 | Mean | |
11/0395 -1 | 6:50 | 8:08 | 9:13 | 8:53 | 8:16 |
Controls: | |||||
PC: Sodium Hydroxide, solid | 11:50 | - | - | - | - |
NC: 10% citric acid | NB | - | - | - | - |
Table3: Historical Control Data
mean [min:s] | SD [min:s] | |
Positive Control (NaOH, solid) | 12:34 | 02:43 |
Negative Control (10% citric acid) | NB | - |
NB = No Breakthrough
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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