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Diss Factsheets
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EC number: 202-501-1 | CAS number: 96-34-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Experimental results are available from studies conducted in fish with the substance methyl chloroacetate. However, no analytical monitoring was conducted during the studies. Therefore, there is no evidence that the concentration of the substance was maintained during the tests. ECOSAR calculations were conducted for both methyl chloroacetate and the analogue ethyl chloroacetate. The outcome of this calculations is that the LC50 values for fish for both substances are below 1 mg/l. These results support the classification for methyl chloroacetate as Hazardous for the Aquatic Environment, Acute Category 1.
The analogue ethyl chloroacetate which shares the same functional group with methyl chloroacetate, also has comparable values for the relevant molecular properties for the aquatic toxicity endpoint. These properties are:
- a low log Pow value which is 0.94 -1.12 for ethyl chloroacetate and 0.63 for methyl chloroacetate,
- a high water solubility which is 20 g/l at approximately 20 ºC for ethyl chloroacetate and 51.6 g/l for methyl chloroacetate and
- similar molecular weights which are 122.55 for ethyl chloroacetate and 108.52 for methyl chloroacetate.
The analogue ethyl chloroacetate is included in the list of harmonised classifications and labellings and it is classified as Hazardous for the Aquatic Environment, Acute Category 1.
Experimental results are available from a study conducted in Daphnia with the substance methyl chloroacetate. The EC50 for Daphnia was concluded to be 5.5 mg/l. However, no analytical monitoring was conducted during the study. Therefore, there is no evidence that the concentration of the substance was maintained during the test. A QSAR prediction conducted with the Multicase model and reported in the Danish EPA database, provides a 48 -h LC50 for methyl chloroacetate of 1.66 mg/l. The data used in the model come from an EC50 for the analogue ethyl chloroacetate which is reported in a publication with a value of 1.6 mg/l. Using the read-across approach based on the analogue ethyl chloroacetate, an EC50 value of 1.42 mg/l is calculated for methyl chloroacetate on Daphnia magna.
Based on the QSAR prediction for the analogue ethyl chloroacetate (48 h EC50 = 20.8 mg/l; Multicase model; Danish EPA) and the molecular weights, the read-across approach is applied and for algae the EC50 for methyl chloroacetate is calculated to be 18.33 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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