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Diss Factsheets
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EC number: 221-499-3 | CAS number: 3121-61-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. An increased application volume of 1 mL was used. Only 4 and 48 h readings were performed; the study was terminated after 48 h. No erythema or edema scores were given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 1mL of the test substance was applied (instead of 0.5 mL); only 4 h and 48 h readings, no scores
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 49 CFR 173.1200 Method of testing corrosion to skin
- Deviations:
- yes
- Remarks:
- 1mL of the test substane was applied (instead of 0.5 mL)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methoxyethyl acrylate
- EC Number:
- 221-499-3
- EC Name:
- 2-methoxyethyl acrylate
- Cas Number:
- 3121-61-7
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-methoxyethyl acrylate
- Details on test material:
- - Name of test material (as cited in study report): Sipomer MCA, 2-Propenoic acid, 2-methoxyethyl ester
- Physical state: clear liquid
- Analytical purity: 99%
- Lot No.: E169H8
- Other: pH not available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Skippack, Farms, Skippack, Pa., USA
- Housing: during the study period, the rabbits were individually housed in stainless steel wire bottomed cages.
- Diet: Fisher Rabbit Pellets, ad libitium
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.0-22.2
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 1 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
reading time points: 4 h and 48 h after exposure - Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm2
- Type of wrap if used: the treated skin was covered with a gauze patch, held in place with adhesive tape. The entire trunk was wrapped with a rubberised elastic cloth.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 h
SCORING SYSTEM: corrosion was considered to have resulted if the test substance caused destruction or irreversible alteration of the tissue. Tissue destruction was considered to have occurred if, at any of the readings, there was ulceration or necrosis. Epidermal sloughing, erythema, edema or fissuring were not considered tissue destruction.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: skin corrosion
- Basis:
- other: 5 of 6 animals
- Time point:
- other: 48 h
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At 48 h after exposure, skin corrosion was noted in 5 of 6 rabbits.
- Irritant / corrosive response data:
- At the 4 h reading time point, all six rabbits showed no corrosive effects on skin. At 48 h after exposure, skin corrosion was noted in 5 of 6 rabbits. Only one animal was free of skin corrosivity.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.