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EC number: 203-640-0 | CAS number: 109-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Acceptable report similar to guideline study (IHT; no GLP, TS purity not specified; animals were observed for only 7 days, limited documentation, exposure period of up to 1 hour, concentration of test substance in air mixture was not verified analytically; mortality occurred after 30 min/1 hour exposure).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- (adopted on 1981, 12th May; inhalation hazard test)
- Deviations:
- yes
- Remarks:
- animals were observed for only 7 days, limited documentation, exposure period of up to 1 hour, concentration of test substance in air mixture was not verified analytically
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylmorpholine
- EC Number:
- 203-640-0
- EC Name:
- 4-methylmorpholine
- Cas Number:
- 109-02-4
- Molecular formula:
- C5H11NO
- IUPAC Name:
- 4-methylmorpholine
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Methyl-morpholin
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
no data
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- The test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at 20 °C.
Young adult laboratory rats, 3 or 6 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 10 or 30 min and 1 hour. - Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of test substance weight loss during exposure, and the amount of air used during exposure.
- Duration of exposure:
- ca. 10 - ca. 60 min
- Remarks on duration:
- 10 and 30 minutes as well as 1 hour
- Concentrations:
- 119.5-130.2 mg/l
- No. of animals per sex per dose:
- 3-6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: all rats of a exposure group were weighed before the study and after the 7 days of exposure (survivers), observations were performed, frequency not stated
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Effect level:
- ca. 119.5 - ca. 130.2 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Remarks on result:
- other: All 12 rats survived an exposure to the saturated vapour for 10 minutes. Exposure for 30 min and 1 hour led to death (5/6 and 6/6 animals died respectively).
- Mortality:
- 6/6 rats died when exposed to the saturated vapour of the test substance for 1 hour.
5/6 rats died when exposed to the saturated vapour of the test substance for 30 min.
All 12 rats survived when exposed to the saturated vapour of the test substance for 10 min. - Clinical signs:
- other: 1 hours exposure: vigorous attempts to escape, intense secretion from eyes and nose, dyspnoea, all animals died during the exposure. 30 min exposure: vigorous attempts to escape, intense secretion from eyes and nose, dyspnoea, after some time bloody secre
- Body weight:
- No data
- Gross pathology:
- Blood in the lung and the nose was observed in 3 rats of the 30 min exposure group, no other findings were noted in the other groups, organs were without findings.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- inconclusive as no LC50 value could be determined in this study
- Conclusions:
- In this acute inhalation toxicity test, following mortalities were observed: 6/6 rats died when exposed to the saturated vapour of the test substance for 1 hour, 5/6 rats died when exposed to the saturated vapour of the test substance for 30 min and all 12 rats survived when exposed to the saturated vapour of the test substance for 10 min. The study is considered inconclusive as no LC50 value could be determined in this study.
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