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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted according to GLP and sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): Untreated DPE 75 (XZ 95510)
- Distillate containing 75% diphenylethane (DPE)
- Physical state: Clear, very pale straw-colored liquid
- Storage condition of test material: Room temperature
-Source: Dow Chemical Europe S.A.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Sprague Dawley CFY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Sprague Dawley CFY rats obtained from Interfauna (UK) Limited, Wyton, Huntingdon, Cambridgeshire, were used.
The animals were housed in groups of three in solid floor polypropylene cages furnished with softwood sawdust. The animal room temperature was maintained at 19 to 25°C with 40 to 70% relative humidity. Artificaial lighting provided 12 hours light and 12 hours darkness. The animals were acclimatised for at least three days before treatment and individually identified by ear punching and cage card. The animals had free access to food (Rat and Mouse Expanded Diet No. 1, Special Diet Services Limited, Witham, Essex, UK). Water was provided at all times from glass water bottles.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Four groups, each of three male rats were given a single 24-hour, occluded dermal application to the shaved back at dose levels of 0.05, 1.0, 2.0 or 4.0 ml/kg or g/kg. Liquid testmaterial was used undiluted. The test site was covered with aluminium foil and secured by adhesive tape.
- Duration of exposure:
- 24 hours
- Doses:
- 0.05, 1.0, 2.0 or 4.0 ml/kg
- No. of animals per sex per dose:
- 3 male rats/dose
- Control animals:
- no
- Details on study design:
- Four groups, each of three male rats were given a single 24-hour, occluded dermal application to the shaved back at dose levels of 0.05, 1.0, 2.0 or 4.0 ml/kg or g/kg. Liquid testmaterial was used undiluted. The test site was covered with aluminium foil and secured by adhesive tape.
Animals were observed for overt systemic toxicity and mortality one and four hours after dosing and then at least once daily for seven days. Individual bodyweights were recorded on the day of treatment. No necropsies were performed.
Using the mortality data an estimate of the acute dermal LD50 of the test material was made. - Statistics:
- None
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 4 mL/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: Animals treated with 4.0 ml/kg showed signs of toxicity on the day of dosing including lethargy, decreased respiratory rate, vocalisation, increased lacrimation and red/brown staining around the eyes and snout. All animals in the 2.0 m l /kg dose group sh
- Gross pathology:
- No data
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The estimated acute dermal LD50 in the male rat following a single, 24 hour, occluded application to intact skin was greater than 4.0 ml/kg.
- Executive summary:
Untreated DPE 75 (75% diphenyl ethane), a potential thermal oil, was provided for toxicity, testing by the Olefin Derivatives Department, DCE. It was tested for oral and dermal toxicity in groups of 3 male rats. Administration of up to 4.0 ml/kg dermally resulted only in non-specific signs of treatment which were absent after 3 days.
Skin irritation studies were performed with 3 New Zealand White rabbits in each case. A 4 hour dermal application of 0.5 ml/kg resulted in erythema and oedema in all rabbits which lasted for more than 3 days but had recovered by 7 days.
Untreated DPE75 has very low toxicity by dermal routes.
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