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Diss Factsheets
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EC number: 245-846-3 | CAS number: 23727-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The acute oral toxicity for (+) CAMPHOLENIC ALDEHYDE was determined to be > 2000 mg/kg bw according to a study performed in agreement with OECD Guideline 401.
(-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- (-) CAMPHOLENIC ALDEHYDE is an isomer of (+) CAMPHOLENIC ALDEHYDE. Data on (+) CAMPHOLENIC ALDEHYDE can be extrapolated to (-) CAMPHOLENIC ALDEHYDE.
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: Just after the treatment, and during the first six hours following administration of the test substance, a slight piloerection was noticed in all animals with a decrease in motor activity and in muscle tone (staggering gait) appearing 1 hour after treatme
- Gross pathology:
- Gross necroscopy of animals 14 days after treatment did not show any visible organic or tissular lesions which may imply a possible systemic toxicity of the test substance.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the acute oral toxicity of the test substance was determined to be LD50 >2000 mg/kg bw.
- Executive summary:
In a GLP compliant acute oral toxicity study conducted in line with standardised guideline OECD 401, the acute oral toxicity of the test substance was determined. Under the conditions of the test, the LD50 of the test substance in rats was determined to be >2000 mg/kg bw and so the substance is considered to be unclassified for acute oral toxicity.
Reference
Table 1: Individual animal bodyweights
Animal number | D1 | D4 | D8 | D15 | D15 -D1 |
Male | |||||
9285 |
185.0 | 201.6 | 264.0 | 331.8 | 146.8 |
9286 | 172.2 | 193.3 | 251.8 | 311.0 | 138.8 |
9287 | 180.6 | 202.0 | 264.8 | 324.7 | 144.1 |
9288 | 203.8 | 207.9 | 262.9 | 332.3 | 128.5 |
9289 | 178.4 | 192.3 | 255.4 | 307.7 | 129.3 |
Mean | 184.0 | 199.4 | 259.8 | 321.5 | 137.5 |
SD | 12.0 | 6.5 | 5.8 | 11.6 | 8.4 |
Female | |||||
9290 | 182.2 | 184.5 | 215.7 | 233.2 | 51.0 |
9291 | 187.6 | 199.5 | 238.3 | 264.8 | 77.2 |
9292 | 190.8 | 203.2 | 227.4 | 259.3 | 68.5 |
9293 | 180.8 | 189.4 | 235.9 | 258.6 | 77.8 |
9294 | 172.0 | 189.9 | 221.6 | 238.4 | 66.4 |
Mean | 182.7 | 193.3 | 227.8 | 250.9 | 68.2 |
SD | 7.2 | 7.8 | 9.5 | 14.1 | 10.9 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study is GLP complaint and has Klimisch score of 1.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Substance is an intermediate and only available data need to be submitted.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral
The key study was performed in line with GLP and a standardised guideline at a single dose of 2000 mg/kg. No mortality occurred during the study and so the LD50 for the test substance was set as >2000 mg/kg bw. The study was selected as the key study on the basis that it was performed in line with GLP and a standardised guideline.
Justification for classification or non-classification
Oral
According to Regulation (EC) No 1272/2008, the studies available suggest that the test substance is considered to be unclassified for acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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