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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-486-6 | CAS number: 60-80-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Non-human data:
The test substance phenazone was investigated for genotoxic effects in three in vitro studies.
In a reverse gene mutation assay in bacteria, strains TA100, TA1535, TA98, TA1537, TA1538 of S. typhimurium and Escherichia coli Wp2 uvrA trp- were exposed to phenazone at concentrations of 0, 4, 20, 100, 500, 2500, 5000, 10000 ug/plate in the presence and absence of mammalian metabolic activation (S9 mix). The test chemical did not induce mutations in the S. typhimurium and E. coli strains, with and without metabolic activation.
In a micronucleus assay study [OECD 474] phenazone was administered by gavage at doses of 0, 63, 200 and 630 mg/kg bw/day in NMRI mice (Horstmann et al., 1984). In this assay phenazone did not induce significant micronuclei in polychromatic erythrocytes.
A study to investigate chromosome aberrations in rats after oral administration of phenazone (5300 ppm) for 117 weeks did not detect increased aberrations in peripheral blood lymphocytes (after stimulation with PHA).
Human data:
No data available.
Short description of key information:
The test substance phenazone was investigated for genotoxic effects in three different in vitro studies. Phenazone was not considered mutagenic in the Ames test with and without metabolic activation (S9). A micronucleus test with NMRI-mice revealed no mutagenic effects. A study to investigate chromosome aberrations in rats could not detect increased aberrations in peripheral blood lymphocytes.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on results of three genetic toxicity studies, phenazone was not classified and labelled as genotoxic according to Directive 67/548/EEC (DSD) and to Regulation 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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