Disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Data is from experimental study report

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Qualifier:

according to guideline

Guideline:

other: the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

no

Type of method:

pour and tap (for solids)

Key result

Type:

pour density

Density:

0.448 g/cm³

Temp.:

20 °C

Remarks on result:

other: 976.8 hPa

Key result

Type:

tap density

Density:

0.607 g/cm³

Temp.:

20 °C

Remarks on result:

other: 976.8 hPa

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observed Values
		1st Observation	2nd Observation
Guideline	OECD 109
Method	Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of Method	Pour Density:It is the ratio of known weight of test substance and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test substance measured before & after tapping in the graduated glass cylinder.
Test temperature	(°C)	29.7°C	30.8 °C
Atmospheric pressure	(hPa)	978.4	975.2
Weight of test item(m)		20	20
Volume of measuring cylinder; readability in g		50 ml;1ml	50ml;1 ml
Volume of test item without tapping (V)		49 ml	41ml
Volume of test item after tapping ( V1)	After 10 tapping	42ml	39 ml
	After 50 tapping	32	34
	After 100 tapping	32	34
	After 250 tapping
	After 500 tapping
	After 750 tapping

*ρat=density of air at 27°C and 760 mm Hg pressure= 0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

CALCULATIONS:

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters	Details	Calculated value		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	= m /V	0.4081	0.4878	0.4479
Tap density of test Item (g/cm³)	= m /V1	0.6250	0.5882	0.6066

Conclusions:

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test substance was determined to be 0.4479 g/cm³ and 0.6066 g/cm³at 20°C and 976.8 hPa.

Executive summary:

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test substance was determined to be 0.4479 g/cm³ and 0.6066 g/cm³at 20°C and 976.8 hPa.

Description of key information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test substance was determined to be 0.4479 g/cm³ and 0.6066 g/cm³at 20°C and 976.8 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.448

Additional information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test substance was determined to be 0.4479 g/cm³ and 0.6066 g/cm³at 20°C and 976.8 hPa.