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EC number: 204-905-3 | CAS number: 128-69-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The substance is applied in the eye of the rabbit undiluted (1x 50 mm3 / 50 mg). Observations are recorded 1 hour, 24 hours, 48 hours, 72 hours, 4 days and 8 days after application.
- GLP compliance:
- no
Test material
- Reference substance name:
- Perylene-3,4:9,10-tetracarboxylic dianhydride
- EC Number:
- 204-905-3
- EC Name:
- Perylene-3,4:9,10-tetracarboxylic dianhydride
- Cas Number:
- 128-69-8
- Molecular formula:
- C24H8O6
- IUPAC Name:
- 7,18-dioxaheptacyclo[14.6.2.2²,⁵.0³,¹².0⁴,⁹.0¹³,²³.0²⁰,²⁴]hexacosa-1(23),2,4,9,11,13,15,20(24),21,25-decaene-6,8,17,19-tetrone
- Details on test material:
- Test materials used in this dossier are all considered to fall under the definition of nano-materials according to the European Commission Recommendation 2011/696/EU as the synthesis and manufacturing of this pigment always yields particulate material with a fine particle size distribution.
Constituent 1
- Specific details on test material used for the study:
- - Physical state: solid (pellets)
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2,95 and 3,0 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: talcum powder was applied into the left eyes and served as control
- Amount / concentration applied:
- 1x 50 mm³ / 50 mg
- Duration of treatment / exposure:
- one single application into the right eye
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- The substance is applied in the right eye of the rabbit undiluted (1x 50 mm3 / 50 mg).
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: minimal effects to the cornea after one hour, reversible within 24 hours
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0.5
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 anf 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: minimal chemosis in one animal after 1 hour of instillation, reversible within 24 hours
- Irritant / corrosive response data:
- 1 hour after application, slight reddening, slight taint and slight cloudiness of the eyes, the eyes were also dyed by the substance, after 24 hours the eyes showed still some slight reddening, after 72 hours no signs of irritation were reported. The initial slight signs of irritation were comparable with the effects of the control, talcum powder, in the eyes of rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions chosen, the test substance was found not to be irritating to eyes.
- Executive summary:
In a non-GLP study according to a method comparable to OECD guideline 405, 50 mg of the test substance was applied undiluted into the conjunctival sac of the right eye of two rabbits. The left eyes were treated with talcum powder and served as controls. One hour after application, slight erythema, slight edema and slight cloudiness of the cornea were observed. The eyes were also dyed by the substance. After 24 hours the eyes showed still some slight reddening, after 8 days no signs of irritation were reported. The initial slight signs of irritation were comparable with the effects of the control. The test article was considered to be not irritating to the rabbit eyes.
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