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Diss Factsheets
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EC number: 700-860-3 | CAS number: 1419401-88-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
To evaluate the aquatic toxicity of the test substance studies on fish, aquatic invertebrates algae, duckweed and microorganisms were performed.
Short-term toxicity to fish
Key study:
In a 96 hour acute toxicity study zebrafish (Danio rerio) were exposed to the test item at nominal concentrations of 0 (control), 4.6, 10, 22, 46, 100 mg/L under static conditions in accordance with the OECD 203 test guideline and EU method C.1 Since the measured concentrations of the test substance in the test solutions were within ±20% of the nominal concentrations, the effect concentration can be expressed relative to the nominal concentration for the evaluation of the test substance. The water, pH, temperature and dissolved oxygen were within acceptable guideline specifications. The 96 hour LC50 was determined to be 67.8 mg/L based on the nominal concentration of the test substance.
Supporting study:
The results of this study are supported by a toxicity screening test with fathead minnow (Pimephales promelas) which was conducted using similar methods as described in the OECD 203 test guideline and EU method C.1. The organisms were exposed for 96 hours to the test item in a static test system to concentrations of 0 (control), 1, 10 and 100 mg/L (nominal). The 96 hour LC50 was determined to be within the range of 10 - 100 mg/L.
Short-term toxicity to aquatic invertebrates
Key study:
In a 48-hour acute toxicity study, neonate Daphnia magna were exposed to the test substance at nominal concentrations of 0 (control), 4.6, 10, 22, 46, 100 mg/L under static conditions in accordance with the OECD 202 guideline and EU-method C.2. Since the analytically determined concentrations of the test substance in the test solutions were within +20% of the nominal concentrations in all affected test groups, the effect concentration can be expressed relative to the nominal concentration for the evaluation of the test substance. The water pH, temperature and dissolved oxygen were within acceptable guideline specifications. Immobilization (mortality) and sublethal effects were observed daily.
The 48 hour EC50 value in this acute toxicity study was determined to be > 100 mg/L based on the nominal concentration of the test substance.
Supporting study:
The results of this study are supported by a toxicity screening test with daphnia magna which was conducted using similar methods as described in the OECD 202 test guideline and EU method C.2. The organisms were exposed for 48 hours to the test item in a static test system to concentrations of 0 (control), 1, 10 and 100 mg/L (nominal). The 48 hour EC50 was determined to be > 100 mg/L.
Toxicity to algae
The determination of the inhibitory effect on cell multiplication of the unicellular green algea (desmodesmus subspicatus) was performed with a screening test using similar methods as described in the OECD 201 test guideline and EU method C.3. The organisms were exposed for 72 hours to the test item in a static test system to concentrations of 0 (control), 1, 10 and 100 mg/L (nominal). The 72 hour EC50 was determined to be in the range of 10 - 100 mg/L.
Toxicity to aquatic plants other than algae
The effect of the test item was evaluated in a 7 day growth inhibition test using the aquatic plant Lemna gibba (duckweed). The test was performed according to OECD guideline 221. Following a preliminary non-GLP range-finding test with concentrations 0 (control), 1.00, 10.0 and 100 mg/L a static main test with concentrations of 0 (control), 0.320, 1.00, 3.20, 10.0, 32.0 and 100 was performed. The concentrations in the main test were verified analytically. Since the measured concentrations of the test substance in the test solutions were within ±20% of the nominal concentrations, the effect concentration can be expressed relative to the nominal concentration for the evaluation of the test substance.
Increase of frond numbers, dry weight, growth rate of frond numbers and growth rate of dry weight, yield of frond numbers and yield of dry weight were the parameters for assessment of toxic effects. The EC50 and the NOEC based on growth rate of dry weight was determined to be 10.7 and 3 mg/L (nominal concentration).
Toxicity to microorganisms
In a test with domestic activated sludge the inhibition of oxygen consumption was examined according to OECD guideline 209.Bacteria were exposed for three hours to the test substance at concentrations of 62.5, 125, 250, 50, 1000 mg/L. No inhibition of respirometric activity in any of the tested concentrations was detected. Thus the determined EC50 and NOAEC values were > 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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