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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Investigation which cannot be subsumed undere a testing guideline, but which is well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studio sulla stabilita degli esteri nel sangue in vitro
- Author:
- S. Ghittore, M. Imnriani, F. Borlini, G. Pezzagno, P. Zadra
- Year:
- 1 984
- Bibliographic source:
- Boll.. Soc. Ital. Biol. Sper. 60811), 2207 - 2213
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Methyl acetate and other esters were adminstered by inhalation. Identification of methyl acetate and conversion products was by GC-MS.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- Methyl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: blood
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
Doses / concentrations
- Dose / conc.:
- 610 mg/m³ air
Results and discussion
- Preliminary studies:
- Hydrolysis of methyl acetate in blood at 37ºC was: concentration: 2.18 μg/L; 7 hours later: 1.96 μg/L.
The products were identified as acetic acid and methanol.
Applicant's summary and conclusion
- Conclusions:
- No bioaccumulation potential based on study results.
Methyl acetate in blood is hydrolysed by forming methanol and acetic acid. - Executive summary:
Methyl acetate in blood is hydrolysed by forming methanol and acetic acid.
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