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EC number: 272-342-0 | CAS number: 68814-89-1 A complex combination of hydrocarbons obtained as the extract from a solvent extraction of heavy paraffinic distillate.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted similar to OECD Test Guideline 404.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Light paraffinic distillate solvent extract (CAS# 64742-05-8)
- IUPAC Name:
- Light paraffinic distillate solvent extract (CAS# 64742-05-8)
- Details on test material:
- Treated distillate aromatic extracts (TDAEs) are a further processing of distillate aromatic extracts (DAEs) in an attempt to reduce the amount of 3-7 ring PAC that is present. Since the treatment is mostly a selective reduction of PACs, the data from DAEs can serve as read across where treatment was insufficient and a significant amount of PACs still remain (≥ 3 wt% DMSO extractables as measured by IP-346).
- Name of test material (as cited in study report): API 83-16
- Physical state: liquid, brown
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Dutchlant, Inc., Denver, Pennsylvania
- Weight at study initiation: 2,834 grams (mean)
- Housing: maintained individually in screen-bottom cages
- Diet (e.g. ad libitum): Purina certified rabbit chow 5322 ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-24
- Humidity (%): 56-70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12/06/84 To: 12/20/84
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact site on each rabbit
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL per area - Duration of treatment / exposure:
- 24 hour
- Observation period:
- 24 and 72 hours, 7 and 14 days
- Number of animals:
- 6 male
- Details on study design:
- TEST SITE
- Area of exposure: one intact site and one abraded site per rabbit
- Type of wrap if used: 2.5x2.5 cm gauze patch, secured with paper tape and overwrapped with saran wrap and elastoplast tape to maintain the test material in contact with the skin and decrease the rate of evaporation
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with wet disposable paper towels
- Time after start of exposure: 24 hours
SCORING SYSTEM: Draize (1959)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- other: 24 and 72 hours
- Score:
- 2.42
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- intact skin
- Time point:
- other: 24 and 72 hours
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritant / corrosive response data:
- The test material produced slight to severe levels or irritation to the skin of rabbits.
- Other effects:
- No sign of ill health was observed during the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified under EU DSD criteria; exposure period was 24 hours
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the mean (24 and 72 hour, intact skin) erythema and oedema scores were 2.45 and 2.5, respectively.
- Executive summary:
Justification for Read Across
Treated distillate aromatic extracts (TDAEs) are a further processing of distillate aromatic extracts (DAEs) in an attempt to reduce the amount of 3-7 ring PAC that is present. Since the treatment is mostly a selective reduction of PACs, the data from DAEs can serve as read across where treatment was insufficient and a significant amount of PACs still remain (≥ 3 wt% DMSO extractables as measured by IP-346). Where treatment was sufficient to reduce the 3-7 ring PACs (<3 wt% DMSO extractables as measured by IP-346), the material is most similar to a lubricating base oil and it is this data that should be used for read across.
In a primary dermal irritation study,white rabbits (6 male) were dermally exposed to 0.5 mL of light paraffinic distillate solvent extract for 24 hours to both an intact skin site and abraded skin site. Animals then were observed for 14 days. Irritation was scored by the method of Draize (1959). The mean (24 and 72 hour, intact skin) erythema and oedema scores were 2.45 and 2.5, respectively. In this study, light paraffinic distillate solvent extract is not classified under EU DSD criteria; exposure period was 24 hours.This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted similar to OECD Test Guideline 404.
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