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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 468-100-0 | CAS number: 376608-74-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Guidance on Safe Use
Administrative data
First-aid measures
- Inhalation: Assure fresh air breathing. Place the victim in semi-seated position. Allow the victim to rest. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Obtain medical attention if breathing difficulty and/or other complaints appear.
- Skin contact: Rinse immediately with plenty of water, for at least 5 minutes. Remove contaminated clothing and shoes. Continue to flush with lukewarm water for 15 minutes. Eventually wash skin with mild soap and water. Obtain medical attention if ill effect or irritation develops.
- Eye contact: Rinse immediately with plenty of water, for at least 15 minutes. Obtain medical attention if pain, blinking, tears or redness persist.
- Ingestion: DO NOT INDUCE VOMITING. Rinse mouth. If swallowed, give 1 pint ofwater if victim completely conscious/alert. Seek medical advice.
- Note to physician: Treat symptomatically. No specific antidote known.
Fire-fighting measures
- Flammable class : -
- Extinguishing media
* Suitable : Water. Dry chemical. Foam.
* Not to be used : Carbon dioxide.
- Surrounding fires : Apply water spray or fog to cool nearby equipment. Use water spray or fog for cooling exposed containers.
- Special exposure hazards : Can form flammable dust clouds in air. Dust clouds mayu be extremely sensitive to air in case of ignition by electrstatic discharge or oether sources of ignition. Under fire conditions, highly hazardous fumes will be present: CO, CO2, Cl-compounds & S-compounds.
- Protection against fire : Use self-contained breathing apparatus (cfr. EN 137) and standard firefighting gear (cfr. EN 469) when in close proximity to fire. Exercise caution when fighting any chemical fire.
Accidental release measures
- Personal precautions : Avoid dust production. Wear self-contained breathing apparatus, and protective clothing. Keep public away from danger area.
- Environmental precautions : Prevent entry to sewers and public waters.
- After spillage and/or leakage : Sweep or shovel spills into appropriate container for disposal.
Handling and storage
- General : Avoid dispersion as a dust cloud.
- Prevention : Handle the product in closed equipment and if possible under an inert atmosphere. Sufficient local or general ventilation. Explosion proof electrical equipment . Earth the equipment and take enough time to remove the electrostatic charges. Do not use compressed air to handle the product.
- Storage : May be stored at ambient temperature. Protect from low temperatures. Protect from high temperature. Store in dry, well-ventilated area. Keep container closed when not in use. Eliminate every possible source of ignition. Keep away from food, drink and animal feeding stuffs.
- Storage - away from : Avoid prolonged storage at elevated temperatures (>20°C). Sources of ignition.
- Suitable packaging: : The product is stored in UN certified packaging: a double PE liner, packed in a fibredrum (1G/X../S). Use antistatic packing to store the product, to prevent electrostatic discharge when emptying the packing.
- Handling : Avoid all unnecessary exposure. Do not breathe dust. Ensure prompt removal from eyes, skin and clothing. Handle in accordance with good industrial hygiene and safety procedures. Keep away from food, drink and animal feeding stuffs. Wear suitable protective clothing.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- UN3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (UL125), 9 (9E), III, (E)
- Chemical name:
- 2-{[(3aR,4S,6R,6aS)-6-{[5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl]amino}-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy}ethanol
- Language:
- English
- Labels:
- 9
SpecialProvisionsopen allclose all
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Marine transport (UN RTDG/IMDG)
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3077
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Special provisions / remarks
- Remarks:
- Passenger/Cargo: 911
Cargo only: 911
Emergency response: 9L
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Exposure controls / personal protection
- Respiratory protection : Wear full face dust mask (cfr. EN 136) with P3-dust cannister (cfr. EN 143) for protection against dust.
- Hand protection : Wear suitable synthetic gloves (Category 3, Class 3) resistant to chemical penetration (cfr. EN 374).
- Skin protection : Wear a coverall type 5, specific for manipulation of solids (cfr. ISO 13982-1).
- Eye protection : See respiratory protection.
- Others : Wear suitable safety shoes (cfr. EN 345 S2).
- Industrial hygiene : Emergency eye wash fountains and safety showers should be available in the immediate vicinity of any potential exposure. Open handling not recommended. Use an adapted installation for handling substances not yet fully tested in a closed system, so that the OEL of the product can be established.
Stability and reactivity
- Hazardous decomposition products : On exposure to high temperature, may decompose, releasing toxic gases. CO, CO2 , Cl-compounds & S-compounds.
- Thermal decomposition possible from (°C) : No data available.
- Conditions to avoid : Direct sunlight. Heat. Eliminate every possible source of ignition. Avoid dispersion as a dust cloud.
Disposal considerations
Disposal : Dispose in a safe manner in accordance with local/national regulations. Dispose of this material and its container at hazardous or special waste collection point. Avoid release to the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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