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Diss Factsheets
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EC number: 605-444-4 | CAS number: 166524-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles; however full data on methodology is not given and no information relating to GLP status is provided. An accurate assessment of the study is therefore not considered to be possible. Furthermore it is not possible to determine the classification of the test material based upon the data provided.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 0.1 g of test material was instilled into each conjunctival sac of one rabbit that had been screened for ocular defects and irritation 24 hours prior to dosing. One eye was washed with water after a 30 second exposure, while the other eye was washed after one hour of exposure. Signs of ocular irritation were recorded over a period of 7 days following test material administration. Body weight was recorded on test day 1 and test day 4.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-fluoro-4-hydrazinyl-2-methoxypyrimidine
- EC Number:
- 605-444-4
- Cas Number:
- 166524-64-7
- Molecular formula:
- C5H7FN4O
- IUPAC Name:
- 5-fluoro-4-hydrazinyl-2-methoxypyrimidine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): 5-fluoro-4-hydrazino-2-methoxypyrimidine- Physical state: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 3.18 kgNo further information is provided on test animals and environmental conditions.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL- Amount(s) applied (volume or weight with unit): 0.1 g
- Duration of treatment / exposure:
- One eye was washed after a 30 second exposure, while the other eye was washed after one hour of exposure.
- Observation period (in vivo):
- Signs of ocular irritation were recorded over a period of 7 days following test material administration.
- Number of animals or in vitro replicates:
- 1 female
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing (if done): washed with water.- Time after start of exposure: one eye was washed after 30 seconds of exposure and the other was washed after one hour of exposure.
Results and discussion
In vivo
- Irritant / corrosive response data:
- Moderate pain was noted in the eyes of the rabbit immediately after dosing. Very slight to slight conjunctival inflammation was present in the eyes 1 hour after dosing. Slight to moderate conjunctival inflammation was present 24 hours after dosing. The conjunctival inflammation gradually diminished, and was resolved by 7 days after dosing.
- Other effects:
- The rabbit survived the test period. The animal lost 560 g of body weight during the 7 days after dosing.
Any other information on results incl. tables
Table 1: Individual Body Weight (kg)
Animal | Test day | |
1 | 4 | |
1 | 3.18 | 2.62 |
Applicant's summary and conclusion
- Interpretation of results:
- other: It is not possible to classify the test material based on the available data
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, the test material induced very slight to moderate conjunctival inflammation over the 7 day observation period. As no information is available on the grade of reaction observed at 24, 48 and 72 hours following test material administration, it is not possible to ascertain a classification for eye irritation.
- Executive summary:
The eye irritation potential of the test material was investigated in a study in which 0.1 g of test material was instilled into each conjunctival sac of one female New Zealand White rabbit that had been screened for ocular defects and irritation 24 hours prior to dosing. One eye was washed with water after a 30 second exposure, while the other eye was washed after one hour of exposure. Signs of ocular irritation were recorded over a period of 7 days following test material administration. Body weight was recorded on test day 1 and test day 4.
Moderate pain was noted in the eyes of the rabbit immediately after dosing. Very slight to slight conjunctival inflammation was present in the eyes 1 hour after dosing. Slight to moderate conjunctival inflammation was present 24 hours after dosing. The conjunctival inflammation gradually diminished, and was resolved by 7 days after dosing.
Under the conditions of the study, the test material induced very slight to moderate conjunctival inflammation over the 7 day observation period. As no information is available on the grade of reaction observed at 24, 48 and 72 hours following test material administration, it is not possible to ascertain a classification for eye irritation. As such as endpoint will be considered "data lacking" for classification purposes although the wording of the report suggests that classification of the substance as an eye irritant is probably not required.
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