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EC number: 210-039-7 | CAS number: 603-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-12-03 to 2002-12-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted under GLP conditions in accordance with the official OECD guideline 202 (1984).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- (1984)
- Deviations:
- yes
- Remarks:
- Part I only
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- (1992)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 002/221/2002
Test material
- Reference substance name:
- p,p'-(2-pyridylmethylene)bisphenol
- EC Number:
- 210-039-7
- EC Name:
- p,p'-(2-pyridylmethylene)bisphenol
- Cas Number:
- 603-41-8
- Molecular formula:
- C18H15NO2
- IUPAC Name:
- 4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol
- Test material form:
- solid
1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)- Method: The test medium was prepared as follows: A supersaturated dispersion with a loading rate of 100 mg/L was prepared by weighing 29.9 mg of the test item into 300 ml test water. No auxiliary solvent or emulsifier was used. The test item was mixed into the test water as homogenously as possible by ultrasonic treatment for 15 minutes and by intense stirring for 48 hours at room temperature in the dark to dissolve a maximum concentration of the test item in the dispersion. Then, the supersaturated stock dispersion of the test item was filtered through a membrane filter under vacuum. The test medium was prepared just before the introduction of the daphnids. On request of the sponsor the concentrations of the test item were not analytically verified during the test period.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM- Common name: Daphnia magna, Straus - Strain: Straus- Source: University of Sheffield/UK- Age at study initiation (mean and range, SD): 6-24 hours- Method of breeding: Clone is bred in recontsituted water of the quality identical to the water quality used in the tests (regarding pH, main ions, and total hardness) and under temperature and light conditions identical to those of the tests.- Feeding during test: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 2.5 mmol/L (=250 mg/L) as CaCO3
- Test temperature:
- 20°C
- pH:
- 7.8 to 7.9
- Dissolved oxygen:
- 8.6 to 8.7 mg O2/L
- Salinity:
- not applicable
- Nominal and measured concentrations:
- 100 mg/L test item (nominal)
- Details on test conditions:
- TEST SYSTEM- Test vessel: 100 mL glass beakers, containing 50 ml medium- Type (delete if not applicable): covered with glass plate- Aeration: no - No. of organisms per vessel: 10 per vessel- No. of vessels per concentration (replicates): 2- No. of vessels per control (replicates): 2- Biomass loading rate: the loading rate was lower than one daphnia per 2 mL test solutionTEST MEDIUM / WATER PARAMETERS- Test water: Reconstituted test water (Analytical grade salts were dissolved in purified water being saturated with oxygen prior to testing).OTHER TEST CONDITIONS- Photoperiod: 16-hour light and 8 hour dark- Light intensity: between 550 and 685 Lux
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
A limit test was performed in accordance with the EU Directive 92/69/EEC to demonstrate that the test item has no toxic effect on Daphnia magna up to the highest concentration which could be dissolved in the test water.
In the control and in the undiluted filtrate of the test item (with a loading rate of 100 mg/L) no immobilized test organisms or other signs of intoxication were determined during the test period of 48 hours.
Therefore, the 48 hour NOEC and the 48-hour EC0 of Oxypicoline RF to Daphnia magna were determined to be at least at a loading rate of 100 mg/L. The 48-hour NOEC and the 48-hour EC0 might even be higher, but concentrations in excess of the loading rate of 100 mg/L have not been tested due to the limited water solubility of the test item in the test water. The 48-hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified, since the test item had no toxic effect at a loading rate of 100 mg/L, and thus above the water solubility limit of the test item in the used test water.Applicant's summary and conclusion
- Conclusions:
- In conclusion, the test item Oxypicoline RF had no acute toxic effects on Daphnia magna up to its solubility limit in test water under the present conditions.
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