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EC number: 216-378-7 | CAS number: 1569-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key acute oral toxicity study, the LD50 in rats was determined to be 1200 mg/kg bw (Lifestream Laboratories, 1970).
In the key acute vapour inhalation toxicity study, the LC50 in rats was determined to be between 5.6 and 13.3 mg/l (Lifestream Laboratories, 1970).
In the key acute dermal toxicity study, the LD50 in rats was determined to be 7.82 g/kg (Lifestream Laboratories, 1970).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 200 mg/kg bw
- Quality of whole database:
- Two acute oral toxicity studies are available for the registered substance. Neither of these was conducted according to OECD test guidelines or in compliance with GLP. However, the key study followed a protocol that resembled current test guidelines and was considered to be reliable. The supporting study is from a publication with limited details available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- Two acute vapour inhalation toxicity studies are available for the registered substance. Neither of these was conducted according to OECD test guidelines or in compliance with GLP. However, the key study followed a protocol that resembled current test guidelines and was considered to be reliable. The supporting study was a limit test in which all animals died and no LC50 could be established.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 7 820 mg/kg bw
Additional information
Two acute oral toxicity studies are available. The key study (Lifestream Laboratories, 1970) was selected since it closely resembled current test guidelines and was well-reported. The supporting study (Schaefer and Bowles, 1985) is a publication of a dietary study in mice in which only limited details were reported, defines the LD50 as >1000 mg/kg. In the key acute oral toxicity study, the LD50 in rats was determined to be 1200 mg/kg bw (Lifestream Laboratories, 1970). Significant clinical signs were lethargy and ataxia. All animals appeared normal by Day 2. In animals that died, necropsy findings included darkened liver and kidneys. There were no abnormal necropsy findings in animals that survived until the end of the 14-day observation period.
Two acute vapour inhalation toxicity studies are available. The key study (Lifestream Laboratories, 1970) was selected since it closely resembled current test guidelines and was well-reported. The supporting study (Lifestream Laboratories, 1969) was a limit test in which all test animals died and no LC50 could therefore be established. In the key acute vapour inhalation toxicity study, the LC50 in rats was determined to be between 5.6 and 13.3 mg/l (Lifestream Laboratories, 1970). 8 out of 10 rats at 13.3 mg/l died during exposure. The remaining 2 died between 2 and 25 hours after the exposure period. All rats survived at 5.6 mg/l. At 13.3 mg/l lethergy and/or general weakness, lacrimation and ataxia were noted within 60 minutes of the start of the exposure period. Rhinorrhea was noted 60 to 90 minutes from start of exposure. Hyperemia of liver and lungs and presence of blood in the gastro-intestinal tract were noted for animals at 13.3 mg/l. There were no remarkable findings in animals at 5.6 mg/l.
Only one acute dermal toxicity study is available (Lifestream Laboratories, 1970). The test protocol resembled OECD 402 but only two animals were used per sex per dose level. 4/4 rabbits at 15.380 g/kg died, 2 between 6 and 22 hours following dosing and 2 by Day 10. 3/4 rabbits at 10.25 g/kg died by Day 12. 1/4 rabbit at 6.834 g/kg died between 6 and 22 hours following dosing and 1/4 rabbit at 4.556 g/kg died by Day 5. The LD50 was determined to be 7.82 g/kg. Generalised weakness, edema, erythma and drying of the skin at the application sites was noted in all groups. Ischemic lungs, hyperemic liver and necrosis of the skin at the application site were noted in all groups except 3.038 g/kg.
Justification for selection of acute toxicity – oral endpoint
The selected study is the more reliable of two available acute oral toxicity studies.
Justification for selection of acute toxicity – inhalation endpoint
The selected study is the more reliable of two available acute inhalation toxicity studies.
Justification for selection of acute toxicity – dermal endpoint
The selected study is the only acute dermal toxicity study that is available for the registered substance.
Justification for classification or non-classification
Based on the available acute oral and inhalation studies, cyclohexylmercaptan is classified in Acute Toxic Category 4 (oral) with hazard statement H302 "Harmful if swallowed" and Acute Toxic Category 3 (vapour) with hazard statement H331 "Toxic if inhaled" according to the criteria of Regulation (EC) No 1272/2008.
Based on the available acute dermal study, no classification is required for dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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