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EC number: 206-420-2 | CAS number: 338-83-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 March 1994-5 May 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study does not indicate adherence to GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- T-5912
- IUPAC Name:
- T-5912
- Details on test material:
- - Name of test material (as cited in study report): T-5912
- Substance type: Clear, colorless liquid
- Physical state: Liquid
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: HRP, Inc., Kalamazoo, MI
- Age at study initiation: adult
- Weight at study initiation: 3027-3471
- Housing: indivudal screen-bottom cages
- Diet (e.g. ad libitum): controlled
- Water (e.g. ad libitum): controlled
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): controlled
- Humidity (%): controlled.
- Air changes (per hr): not stated
IN-LIFE DATES: From: 31 March 1994 To: 3 April 1994
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye served as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0-.1 mL - Duration of treatment / exposure:
- Only for a few seconds during test substance instillation
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3/sex/dose
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Sodium fluorescein examination was dose to reveal potential corneal injury
- Time after start of exposure: 72 hours
SCORING SYSTEM: Draize (1959) technique
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Primary Irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- 0% of the test animals at all time points responsed to the test article.
Any other information on results incl. tables
All cornea, iris, and conjunctivae irritations cores were zero for all animals at all time points. The sodium fluorescein examination was negative, indication no corneal damage.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- The test article, T-5912, when evaluated for its primary eye irritation potential in rabbits, produced no occular irritation.
- Executive summary:
The ocular irritation/corrosion potential of T-5912 was assessed in New Zealand White rabbits. The undiluted test article (0.1 mL) was placed into the everted lower lid of the right eye, with the left eye serving as the untreated control. The upper and lower lids were held together for 1 second and then released. The eyes remained unflushed. The treated eyes were observed for ocular irritation at 1, 24, 48 and 72 hours after treatment. Irritation was scored using the Draize technique. A sodium fluorescein examination was used to reveal possible corneal damage at 72 hours. Average primary irritation scores and individual eye irritation scores for cornea, iris, conjunctivae irritation were reported. All animals and all time points had irritation scores of zero. The test article, T-5912, when evaluated for its primary eye irritation potential in rabbits, produced no ocular irritation.
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