Registration Dossier
Registration Dossier
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Diss Factsheets
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EC number: 202-802-8 | CAS number: 99-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4'-hydroxyacetophenone
- EC Number:
- 202-802-8
- EC Name:
- 4'-hydroxyacetophenone
- Cas Number:
- 99-93-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 1-(4-hydroxyphenyl)ethan-1-one
- Details on test material:
- Name of the test substance used in the study report: C-01650 (4-HAP)
purity: 99.97%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Approximately weight = 2.0 - 3.0 kg at time of dosing. Animal weights fell within 20% of the group mean.
Each animal was assigned an unique and individual number. This number was permanently indicated on the animal with an ear tag.
Animals were housed separately from any other species. They were individually housed in stainless steel, wire mesh bottom cages.
Room temperature: 63 - 73°F; relative humidity: 30 - 70%; day/night rhythm: 12 h dark, 12 h light.
Fresh certified feed and fresh potable water was provided ad libitum.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approxiniately 24 hours prior to dermal administration, the hair was clipped from the dorsal area of the animals. Five male and five female rabbite were randomly selected by a computer randomization program. Animals were selected based on their body weight the day of dosing. Undiluted test article was administered demally to five male and five female rabbits at a dose of 2.0 g/kg. Individual doses were adjusted based on tbe animal's body weight on the day of dosing. Immediately after test article administration, the application site was moistened sufficiently with sterile water to ensure good contact with the skin and then occlusively wrapped for 24 hours.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Observations were made hourly for the first 4 hours immediately after dosing and twice daily (a.m. and p.m.) for the next 13 days for a total of 14 days of observation.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None of the animals died during the study period.
- Clinical signs:
- other: All of the animals on the study exhibited one or more of the following observations: abnormal stools, ocular discharge, erythema, and edema at the test site. By day 13, none of the animals had any observable abnormalities.
- Gross pathology:
- All of the animals were necropsied on the day following the last observation. All of the animals exhibited no visible lesions at necropsy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.