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EC number: 946-245-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 Sep 1980 to 17 Sep 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of (E)-3,4,5,6,6-pentamethylhept-3-en-2-one and 3,5,6,6-tetramethyl-4-methyleneheptan-2-one
- EC Number:
- 946-245-5
- Molecular formula:
- C12H22O
- IUPAC Name:
- Reaction mass of (E)-3,4,5,6,6-pentamethylhept-3-en-2-one and 3,5,6,6-tetramethyl-4-methyleneheptan-2-one
- Test material form:
- liquid
- Details on test material:
- According to ECHA communication with reference to Annotation number: SUB-C-2114629169-42-01/F, the substance ID for Koavone has been changed with EC# from 939-627-8 to 946-245-5, and the IUPAC name from Reaction mass of (3R,5R)-3,5,6,6-tetramethyl-4-methylideneheptan-2-one and (3R,5S)-3,5,6,6-tetramethyl-4-methylideneheptan-2-one and (E)-3,4,5,6,6-pentamethylhept-3-en-2-one to Reaction mass of (E)-3,4,5,6,6-pentamethylhept-3-en-2-one and 3,5,6,6-tetramethyl-4-methyleneheptan-2-one.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hilltop Lab Animals, Inc.
- Age at study initiation: Approximately 6 weeks
- Weight at study initiation: male rats was 197 to 234 grams and for the female rats was 141 to 181 grams
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 7 days
- Housing: The rats were individually housed in stainless steel cages suspended above the droppings..
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 3 Sep 1980 to 17 Sep 1980
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The dorsal skin area centered about the interscapular region. The fur was removed with an electric clipper the previous day.
TEST MATERIAL
- Amount applied: 0.5 mL/100 gram of body weight (applied in small aliquots of 0.25 mL to reduce run-off)
OTHER:
The substance had a density greater than 1.0 g/mL. The 5.0 g/kg dosage was administered at a rate of 0.7 mL/100 mg of bw. - Doses:
- - 0.59 g/ kg bw
- 1.0 g/ kg bw
- 1.69 g/ kg bw
- 2.88 g/ kg bw
- 5.0 g/ kg bw - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1-2, 3-4, 4-5 and 24 hours after dosing and twice daily during the remainder of the 14- day observation period
- Necropsy of survivors performed: yes
- Clinical signs including body weight : Clinical signs were observed during the 14-d observation period, at the end of the 14- day observation period the rats were weighed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred
- Clinical signs:
- other: No signs
- Gross pathology:
- At termination, gas in the intestines was observerd in most of the males and a few females. No other gross pathology was noted.
Applicant's summary and conclusion
- Interpretation of results:
- other: not harmful
- Remarks:
- in accordance with EU CLP (EC no 1272/2008 and its amendments)
- Conclusions:
- Not harmful. The dermal LD50 value of the substance was found to be greater than 5.0 g/kg bw day in both sexes tested using a method similar to OECD 402.
- Executive summary:
The dermal LD50 determination in male and female Sprague-Dawley derived albino rats of the substance was performed. Groups of ten male and ten female Sprague-Dawley rats received a single dermal dosage of the substance dissolved in a diluent. Dosages were 0.59, 1.0, 1.69, 2.88 and 5.0 g/kg bw day. All animals were observed for mortality and signs of toxicity. At the end of the 14-day observation period, the rats were weighed and sacrificed. Results showed that there was no mortality, and no clinical signs were observerd during the 14-day observation period. At termination, gas in the intestines was observed in most of the males and a few females. No other gross pathology was noted. All rats gained weight during the observation period. The dermal LD50 value of the substance was found to be greater than 5.0 g/kg bw day in both sexes. Based on this result, the substance is not harmful in accordance with EU CLP (EC no 1272/2008 and its amendments).
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