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Diss Factsheets
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EC number: 941-802-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, according to guideline, no deviations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,4-di-tert-butylphenyl diphenyl phosphite; 2-tert-butylphenyl diphenyl phosphite; 4-tert-butylphenyl diphenyl phosphite; triphenyl phosphite
- EC Number:
- 941-802-9
- Molecular formula:
- Unspecified
- IUPAC Name:
- 2,4-di-tert-butylphenyl diphenyl phosphite; 2-tert-butylphenyl diphenyl phosphite; 4-tert-butylphenyl diphenyl phosphite; triphenyl phosphite
- Test material form:
- other: yellowish liquid
- Details on test material:
- expiration date April 30, 2003
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- duplicate samples: 0, 48, 96 hours (except for loading rates of 46mg/L, 100 mg/L: sampling only before the strat of the test)
The two lowest test concentrations with loading rates of 4.6 and 10 mg/L were not analyzed, since they were below the 96-hour NOEC, determined in this test.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- mixing 23, 50, 111, 232 and 499 mg test item into 5000 mL test water each. No auxiliary solvent or emulsifier was used. The test item was mixed into the test water as homogeneously as possible by ultrasonic treatment for 15 minutes and by intense stirring on a magnetic sfirrer at room temperature in the dark for 96 hours. A stirring period of 96 hours was chosen to dissolve a maximum concentration of the test item in test water.
These saturated aqueous dispersions were filtered through a membrane filter (Schleicher & Schuell, Type NC20, pore size 0.20 pm) just before the start of the test. The negative pressure of the filtration unit was reduced as far as possible not to suck the liquid test item through the filter and to avoid losses of volafile components of the test item during filtration.
The undiluted filtrates of the dispersions with dissolved test item were tested on fish as WAFs. Addifionally, a control was tested in parallel.
The test media were freshly prepared just before introduction of the fish. The actual concentrations of the test item in the test media were analytically determined.
The loading rates were based on the results of a range-finding test and on the results of a first main test.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- The study was performed with zebra fish (Brachydanio rerio). The test fish were obtained
from Zoohaus Schaub, CH-4410 Liestal, Switzeriand. In accordance with the test guidelines
the fish were held in the laboratories of RCC for at least three weeks without any medication.
Prior to the test start, they were acclimated for one week to the test water and temperature.
During holding and acclimatization unfil one day before the start of the test the fish were fed
with a commercial fish diet (TETRA MIN Hauptfutter, supplied by TETRA-Werke, D-49304
Melle, Germany). During holding and acclimatizafion no fish died in the test fish batch and all
fish were healthy.
From the acclimated test fish batch, 10 fish were measured at the start of the test: The mean
body length of the fish was 3.1 ± 0.15 cm (Mean ± SD), the mean body wet weight was
0.24 ± 0.04 g (Mean ± SD).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5 mmol/L as CaCO3
- Test temperature:
- 21-22°C
- pH:
- 7.8-8
- Dissolved oxygen:
- >= 7.9 mg/L
- Nominal and measured concentrations:
- WAFs: 4.6, 10, 22, 46, 100 mg/L
- Details on test conditions:
- One glass aquarium with 4 liters test medium was used for each test concentration and the control. At the start of the test 7 fish were
introduced into each aquarium in a random order. The loading rate was 0.42 g fish wet weight per liter test medium. The test media and the control were slightly aerated during the test period. The fish were not fed during the test.
Reconstituted water: analytical grade salts were dissolved deionized water to obtain the following nominal concentrations:
in
CaCl2 X 2H2O 2.0 mmol/L (= 294 mg/L)
MgSO4 X 7H2O 0.5 mmol/L (=123 mg/L)
NaHCO3 0.75 mmol/L (= 65 mg/L)
KCl 0.075 mmol/L (= 5.8 mg/L)
Alkalinity 0.8 mmol/L
Ratio of Ca : Mg 4 : 1 (based on molarity)
Na:K 10 : 1 (based on molarity)
The test water was aerated prior to the preparation of the test media until oxygen saturation was reached.
Photoperiod of 16 hours light and 8 hours darkness (with a 30 minute transition period). Light intensity at light period approximately 190-500 Lux.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WAF
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WAF
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WAF
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WAF
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WAF
- Details on results:
- all test solutions were clear throughout the test
The LC50 and the 95% confidence interval at the observation dates could not be calculated by Probit Analysis or Moving Average Interpolation due to the steep concentration-effect relationship. Instead the LC50-values were determined as the geometric mean value of the two consecutive test concentrations with 0% and 100% mortality, and the 95% confidence intervals for the LC5O as the test concentrations with 0% and 100% mortality. The NOEC and the LCO were determined directly from the raw data. All calculations are based on the loading rates of the test item.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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