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EC number: 255-419-3 | CAS number: 41506-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study OECD405, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(4-acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide
- EC Number:
- 255-419-3
- EC Name:
- N-(4-acetylaminophenyl)-3-hydroxynaphthalene-2-carboxamide
- Cas Number:
- 41506-62-1
- Molecular formula:
- C19H16N2O3
- IUPAC Name:
- N-(4-acetamidophenyl)-3-hydroxy-2-naphthamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hoechst Kastengrund, Germany
- Strain: Albino New Zealand rabbit, normal breeding
- Age at study initiation: ca. 3 - 5 months
- Weight at study initiation: 3.4 - 4.3 kg
- Housing: single cages arranged in a battery
- Diet: Altromin 2123 ad libitum + straw
- Water : de-ionized and chlorinated water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+/- 3
- Humidity (%): 50 +/- 20
- Lighting time: 12 h daily
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated right eyes served as control
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 72 h after beginning of treatment
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- About 24 hours before the start of the study the test eyes of all animals were examined under UV light for corneal lesions after instillation of one drop of a 0.01 % fluorescein-sodium solution. Only animals without ocular abnormalities were used for the study.
100 mg of the test substance was applied once to the conjunctival sac of the left eye of three rabbits. The untreated right eyes served in each case as a control.
24 hours after application and at all other designated examination times at which the treated eyes still showed discharge or at which a corneal examination with fluorescein sodium solution took place, the treated eyes were washed out thoroughly with isotonic saline at approx. 37°C.
The eyes were examined 1, 24, 48 and 72 hours after application of the test substance. At 24 and 72 hours the eyes were also examined for corneal lesions under UV light after instillation of one drop of 0.01 % fluorescein-sodium solution. Lesions in cornea, iris or conjunctivae were graded numerically. All other changes or toxic effects were recorded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant since no effect occured
- Remarks on result:
- other: no effect on any single animal
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not relevant since no effect occured
- Remarks on result:
- other: no effect on any single animal
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0.6
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h after treatment
- Remarks on result:
- other: highest mean score of two single animals: 0.7
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant since no effect occured
- Remarks on result:
- other: no effect on any single animal
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification acc. to (EC) 1272/2008: not irritating
- Executive summary:
Test material was subject to a test of eye irritancy according to OECD Guideline 405. 100 mg of substance were applied to one eye of three animals.Mean values of the 24, 48 and 72 h readings were calculated for each animal. Only slight effects (conjunctival redness mean score: <=0.6, corneal opacity, iridial effects, chemosis mean score of each: 0) below the threshold for classification were determined. All effects were fully reversible.Based on these findings the test material was judged no to be irritating to the eye.
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