Registration Dossier
Registration Dossier
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EC number: 428-410-9 | CAS number: 67014-36-2
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis
Hydrolysis of the test substance was studied in the dark at 50 ºC in sterile aqueous buffered solutions at pH 4 , pH 7 and pH 9 for 5 days. The experiment was conducted in accordance to EU method C.7 and in compliance with the GLP standards. Samples were analyzed at 0, 2.4 hours and 5 days by HPLC/UV. At test termination, the concentration of the test substance decreased from 100% at day 0, to 94% of the initial at pH 4, from 100 to 93% of the initial at pH 7, and from 100 to 95% of the initial at pH 9. No transformation of the test substance was observed.
At pH 4, pH 7 and pH 9, a decrease in concentration < 10% was observed after 5 days (half-life time at 25 °C > 1 year). Hence it was concluded that the test substance is hydrolytically stable at pH 4, pH 7 and pH 9, under the conditions of the test. (NOTOX B.V., 2000)
Biodegradation
The ready biodegradability of the test substance was tested in a GLP guideline study according to OECD 301 B. The results of this enhanced biodegradation study revealed a biodegradation degree of 1.6 - 1.7% based on CO2 evolution (modified Sturm Test) after a test duration of 28 days. Based on these data, the test substance is considered to be not biodegradable.This study is classified acceptable and satisfies the guideline requirements for biodegradation studies. (NOTOX B.V., 1998)
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