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EC number: 241-756-3 | CAS number: 17773-41-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 22/04/1996 (initiation of the preliminary study) to 04/07/1996 (date of the report)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed in accordance with the EU Directive 92/69/EEC C.2. As the test conditions are not fully described and no analytical monitoring has been performed, this study is considered as reliable with restrictions.
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxy-4-(methylthio)butyronitrile
- EC Number:
- 241-756-3
- EC Name:
- 2-hydroxy-4-(methylthio)butyronitrile
- Cas Number:
- 17773-41-0
- Molecular formula:
- C5H9NOS
- IUPAC Name:
- 2-hydroxy-4-(methylsulfanyl)butanenitrile
- Details on test material:
- See field "Confidential details on test material"
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable.
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- No data available.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No data available.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No data available.
Test conditions
- Hardness:
- No data available.
- Test temperature:
- No data available.
- pH:
- No data available.
- Dissolved oxygen:
- No data available.
- Salinity:
- Not applicable.
- Nominal and measured concentrations:
- Nominal concentrations: 16, 22, 32, 48, 70, 100, 140 and 200 ppm (weight/weight) of the initial aqueous solution 10% HMTBN.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: no data
- No. of organisms per concentration: 20
- No. of organisms per vessel: no data
- No. of vessels per concentration (replicates): no data
- No. of vessels per control (replicates): no data
- No. of vessels per vehicle control (replicates): no data
- Biomass loading rate: no data
TEST MEDIUM / WATER PARAMETERS
No data
EFFECT PARAMETERS MEASURED :
The immobility of the daphnids have been observed at 24 and 48 hours of exposure.
TEST CONCENTRATIONS
No data.
STATISTICAL METHOD:
The CE50-24 and 48 hours and the 95% Confidance Limits have been determined by the probit method. - Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 87 other: ppm (weight/weight)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% LC : 74 - 100 ppm (weight/weight)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 33 other: ppm (weight/weight)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% LC = 25 - 36 ppm (weight/weight)
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.7 other: ppm (weight/weight)
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- non diluted HMTBN
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 3.3 other: ppm (weight/weight)
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Remarks:
- non diluted HMTBN
- Basis for effect:
- mobility
- Details on results:
- The percentage of immobility observed are reported in table 1.
Any other information on results incl. tables
Table 1: Percentage of immobility
Immobility | ||||
Number of daphnids / 20 | % | |||
Concentration in ppm (weight/weight) | 24 hours | 48 hours | 24 hours | 48 hours |
Control | 0 | 1 | 0 | 5 |
200 | 20 | 20 | 100 | 100 |
140 | 17 | 20 | 85 | 100 |
100 | 8 | 19 | 40 | 95 |
70 | 8 | 19 | 40 | 95 |
48 | 3 | 11 | 15 | 55 |
32 | 1 | 12 | 5 | 60 |
22 | 1 | 6 | 5 | 30 |
16 | 1 | 1 | 5 | 5 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the results of this study, HMTBN is considered as Toxic to the aquatic organisms tested in accordance with the Directive 67/548/EC.
- Executive summary:
The ability of HMTBN to immobilise Daphnia magna was tested in an acute toxicity study according to the EU Directive 92/69/EEC C.2.
The following concentrations were tested : 16, 22, 32, 48, 70, 100, 140 and 200 ppm (weight/weight) of test item (aqueous solution 10% HMTBN). No analytical monitoring has been performed. No other information is available on the test conditions.
There was 5% mortality of daphnia magna in the controls at the end of the exposure period (48h). The EC50(48 h)-value was estimated to be 33 ppm (w/w) with a 95% CL of 25 -36 ppm (w/w) based on the test item. This result correspond to an EC50(48 h)-value of 3.3 ppm (w/w) based on HMTBN non diluted.
Based on the results of this study, HMTBN is considered as Toxic to the aquatic organisms tested in accordance with the Directive 67/548/EC.
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