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EC number: 246-904-0 | CAS number: 25371-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Water accomodated fraction (WAF) procedure was applied to prepare the test solutions due to the poor solubility of the test item
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dimethyl octadecylphosphonate
- EC Number:
- 246-904-0
- EC Name:
- Dimethyl octadecylphosphonate
- Cas Number:
- 25371-54-4
- Molecular formula:
- C20H43O3P
- IUPAC Name:
- dimethyl octadecylphosphonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test Item Identification: DURAPHOS 100
Batch: F14E002
Purity: 91.1% dimethyl octadecylphosphonate (DMOP)
Description: White powder
Storage conditions: room tempearure and protected from humidity
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Each test solution was prepared by stirring the test item in M4 reconstituted water at the appropriate loading rate between 20 and 24 hours . After filtration through a filter of porosity 0.45 µm, the water soluble fraction (WSF) was collected and used as the test solution.
Range Finding Test: Nominal Loading Rates of 1 and 10 mg/L.
Limit Test: Nominal Loading Rate of 100 mg/L
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain:STRAUS-clone 5
- Source: CIT
- Age at study initiation: 6-24 hours old (first instar daphnids)
- Method of breeding: produced from parthenogenically reproducing brood female population.
- Feeding during test: animals were not fed during the test
ACCLIMATION
- Acclimation period: acclimitisation from birth
- Acclimation conditions (same as test or not):animals were held in water of the same quality and conditions as test water
- Type and amount of food:culture animals were fed with a diet of between 0.1 and 0.2 mg of carbon per Daphnia, in
the form of the algal strain Scenedesmus subspicatus which was cultured at CIT.
- Feeding frequency: daily
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 303 and 346 mg/L as CaCO3
- Test temperature:
- 19.8 °C to 21.6°C
- pH:
- 7.88 to 8.44 (variation within 1 unit for each test solution)
- Dissolved oxygen:
- 8.4 to 8.8 mg/l (> 3 mg/l)
- Salinity:
- N/A
- Nominal and measured concentrations:
- 100 mg/L (nominal concentration, water-accomodated fraction procedure was used to prepare the test solutions)
- Details on test conditions:
- TEST SYSTEM
- Test solution volume: 50 ml (10 ml per daphnid)
- Aeration: the test vessels were not aerated during the test, however the dilution water was aerated prior to addition of the test item
- Renewal rate of test solution (frequency/flow rate): Not applicable (static test)
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates):4 replicates
- No. of vessels per control (replicates): not applicable (control test was only included in the rangefinding test)
- No. of vessels per vehicle control (replicates): 4 replicates
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: M4 reconstituted water was prepared by the test facility using deionized water
OTHER TEST CONDITIONS
- Photoperiod:16/8 hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :24 and 48 h
TEST CONCENTRATIONS
- test concentration: 0 and 100 mg/L (limit test)
- range finding study: 1 and 10 mg/L - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: water soluble fractions
- Basis for effect:
- mobility
- Details on results:
- Limit Test
There was 0% immobilisation at 0 and 100 mg/L at 24 and 48 h
EL50 (Median Effective Loading rate) :> 100 mg/L.
No Observed Effect Loading rate: ≥ 100 mg/L.
As the test item is poorly soluble in water (estimated solubility < 1 mg/L), the water-accommodated fraction (WAF) procedure was applied to prepare the test solutions. The effect data are therefore presented Loading Rates (Median Effective Loading Rate and No Observed Effect Loading rate).
Rangefinding Test
There was 0% immobilisation at 0 and 10 mg/L at 24 and 48 h - Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EL50 (Median Effective Loading rate) derived from the limit test for dimethyl octadecylphosphonate (DMOP) was > 100 mg/l and the No Observed Effect Loading rate was ≥ 100mg/l. The validity criteria of the test were met (the immobilization in the control was ≤ 10% at the end of the test, the dissolved oxygen concentration remained > 3 mg/L throughout the test and the pH of the control did not vary by more than 1 unit during the test).
- Executive summary:
A 48-hour static acute toxicity test with Daphnia magna was performed in a test designed to meet the requirements OECD Test Guideline 202. As the test item, DMOP (91.1%) is poorly soluble in water (estimated solubility < 1 mg/L); the water-accommodated fraction (WAF) procedure was applied to prepare the test solutions. A WAF is an aqueous medium containing only the fraction of test item (present either in true solution or as a stable emulsion) which remains in the aqueous phase after stirring and phase separation. When filtered through appropriate filters, water-soluble fractions (WSFs) are obtained.
In the limit test where 20 daphnids (4 replicates of 5) were exposed to a nominal loading rate of 100 mg/L (the limit test loading rate) for 48 hours while a second group of 20 daphnids (also 4 replicates of 5) was exposed to dilution test water (M4) only (control solution). In the range finding test, two groups of 20 daphnids (4 replicates of 5) were exposed to nominal loading rates of 1 and 10 mg/l for a period of 48 hours. The test solutions (50 ml per replicate of 5 daphnids) remained unchanged for the duration of the test. Immobilisation in the rangefinding and limit test was recorded at 0, 24 and 48 hours.
No immobilisation was observed in any of the test solutions during the rangefinding test or limit test. The EL50 (Median Effective Loading rate) derived from the limit test for DMOP was > 100 mg/l and the No Observed Effect Loading rate was ≥ 100 mg/l. The validity criteria of the test were met (the immobilization in the control was ≤ 10% at the end of the test, the dissolved oxygen concentration remained > 3 mg/l throughout the test and the pH of the control did not vary by more than 1 unit during the test).
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