Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 April 1991-25 November 1991

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: EPA 63.8

GLP compliance:

yes

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate

EC Number:

407-550-4

EC Name:

Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate

Cas Number:

69184-17-4

Molecular formula:

Hill formula: C8 H7 Cl2 F N2 O3 CAS formula: C8 H7 Cl2 F N2 O3

IUPAC Name:

methyl 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate

Details on test material:

- Name of test material (as cited in study report): Fluroxypyr methyl ester
- Physical state: white crystalline powder
- Analytical purity: 99.7% w/w
- Purity test date: 26.09.1990
- Lot/batch No.: AGR 279096
- Expiration date of the lot/batch: September 1992
- Storage condition of test material: below 5 °C

Results and discussion

Water solubility

Water solubility:

28 mg/L

Temp.:

20 °C

pH:

>= 3.79 - <= 5.14

Details on results:

water solubility: 28.0 ± 1.6 mg/L, coefficient of variation 5.7%. The reason for the pH change is not apparent, but since the results
are reproducible, it is deemed not to be important with respect to the test.

Any other information on results incl. tables

Measurements of water solubility:

Sample number	Time (days)		Concentration (mg/L)	Mean concentration (mg/L)	pH
	Held at 30 °C	Equilibrated at 20 °C
1A, 1B	1	1	26.3, 26.1	26.2	5.14
4A, 4B	8	1	29.1, 27.5	28.3	4.77
5A, 5B	9	1	30.0, 28.8	29.4	3.79

Water solubility was determined as overall (pooled) mean of all tests.

HPLC/UV analysis of samples 1A to 5B:

Standard or Sample	Peak area	Substance (pure, mg/L)	Dilution factor	Substance (pure, mg/L)
0.53 mg/L std	91.863	-	-	-
Sample 1A	221.925	1.32	20	26.3
Sample 1B	220.389	1.31	20	26.1
0.53 mg/L std	86.923	-	-	-
0.53 mg/L std	86.128	-	-	-
Sample 4A	232.695	1.46	20	29.1
Sample 4B	219.837	1.38	20	27.5
0.53 mg/L std	83.319	-	-	-
0.53 mg/L std	76.861	-	-	-
Sample 5A	213.663	1.50	20	30.0
Sample 5B	205.392	1.44	20	28.8
0.53 mg/L std	74.096	-	-	-