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EC number: 293-214-0 | CAS number: 91052-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
No specific toxicokinetic studies are available on Glycerides, C12-18 mono-, di- and tri-. A toxicokinetic assessment was made based on the physico-chemical properties of the test substance and the results of toxicity studies (acute oral toxicity, repeated oral dose toxicity study, skin irritation, eye irritation, skin sensitization and in vitro genotoxicity).
Key value for chemical safety assessment
Additional information
Physico-chemical properties:
Water solubility: 17.2 mg/L (at 20°C)
Partition coefficient in octanol/water: The study will be available December 2018.
Melting point/freezing point: 29.75°C (at 101.325 kPa)
Boiling point: 400.8°C (at 101.325 kPa)
Density: 0.9802 (at 20°C)
Flammability: This substance is not a highly flammability solid.
Absorption:
Oral route:
This is UVCB organic substance with uncertain structure, molecular weight and particle size and so on. The results obtained in the acute toxicity: oral study (OECD 401) and the repeated oral dose toxicity study (OECD 422) confirmed the oral absorption of Glycerides, C12-18 mono-, di- and tri- as no adverse effect observed in both studies. Therefore it can be considered that the absorption resulting from potential exposure by the oral route is limited.
Inhalation:
No data are available for inhalation route of exposure. However, the test substance is a solid and exposure via inhalation is not likely taking into account. Therefore it can be considered that the absorption resulting from potential exposure by the inhalation route is limited.
Dermal route:
No data are available for dermal route of exposure. However, the test substance is a solid and skin contact in production and use is not likely. Also there is no adverse effect observed in the studies of skin irritation, skin sensitization and eye irritation. Therefore it can be considered that the absorption resulting from potential exposure by the dermal route is limited.
Distribution:
In the acute oral toxicity study, no mortality and no overt signs of toxicity were noted as well as no abnormalities were noted at necropsy of animals killed at the end of the study. In the repeated dose oral toxicity study, no toxicologically relevant changes were noted in organ weights and organ to body weight ratios as well as no effects observed in clinical signs, mortality, haematological findings. These results indicate no specific systemic distribution of the test substance and/or its metabolites or degradation products.
Metabolism:
In the acute oral toxicity study and the repeated dose oral toxicity study, no adverse effect is observed. Also in the study of in vitro cytogenicity/chromosome aberration in mammalian cells, no genotoxicity and no cytotoxicity are observed. In the absence of specific metabolism studies, it is not possible to conclude on the metabolisation potential of the substance, but according to the studies above, there seems no adverse effect of the substance and/or its metabolites or degradation products.
Excretion:
There is no indication of a preferred route of excretion for Glycerides, C12-18 mono-, di- and tri- but its water solubility of 17.2 mg/L (at 20°C) and no adverse effect in oral toxicity studies indicates that excretion of unchanged parent substance and/or metabolites could occur by renal or biliary routes and that bioaccumulation is unlikely.
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