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EC number: 277-364-4 | CAS number: 73296-98-7 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Ilex paraguayensis, Aquifoliaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 22 October 2018 and 24 October 2018.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 5 043 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 6 319 Pa
- Conclusions:
- The vapour pressure of the test item is 5043 Pa at 20°C and 6319 Pa at 25°C.
- Executive summary:
The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Temperature/vapour pressure were used to calculate a regressionin a temperature range of 20.1 – 36.1 °C,from which vapour pressure at ambient temperature could be estimated.
From the measured values, the vapour pressure of the test item was calculated as 5043 Pa at 20.0 °C and 6319 Pa at 25 °C.
These values represent the component with the highest vapour pressure.
Reference
Results:
For each experimental temperature (T), log10(p) was calculated from the mean of measured values. A vapour pressure curve was obtained by plotting log10(p) against (1/T), with p in Pa and T in K.
A linear regression was obtained and the vapour pressure of the substance has been calculated at 20°C or 25°C.
Time (hh:mm) |
Pressure (Pa) |
Temperature (°C) |
10:48 |
4679 |
20.1 |
11:52 |
5846 |
24.1 |
13:15 |
7212 |
28.1 |
14:15 |
8588 |
32.1 |
15:00 |
9816 |
36.1 |
15:52 |
9004 |
32.1 |
16:57 |
7693 |
28.1 |
18:00 |
6394 |
24.1 |
20:00 |
5196 |
20.1 |
Data exploitation
Vapour Pressure* (Pa) |
Corresponding Temperature (°C) |
Temperature (K) |
1/T (K-1) |
Log10(p) |
4938 |
20.1 |
293.25 |
3.410E-03 |
3.694 |
6120 |
24.1 |
297.25 |
3.364E-03 |
3.787 |
7453 |
28.1 |
301.25 |
3.320E-03 |
3.872 |
8796 |
32.1 |
305.25 |
3.276E-03 |
3.944 |
9816 |
36.1 |
309.25 |
3.234E-03 |
3.992 |
*: mean of pressures values for increasing and decreasing temperature if available.
A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gives the following statistical data using an unweighted least square treatment.
Slope -1713
Intercept 9.5462
R² 0.9893
The results obtained indicate the following vapour pressure relationship:
Log10(p (Pa)) = -1713 / T (K) +9.5462
The above equation yields a vapour pressure of 5043 Pa at 293.15 K and 6319 Pa at 298.15 K.
Description of key information
The vapour pressure of the test item is 5043 Pa at 20°C and 6319 Pa at 25°C (interpolation).
These values represent the component with the highest vapour pressure.
Key value for chemical safety assessment
- Vapour pressure:
- 6 319 Pa
- at the temperature of:
- 25 °C
Additional information
A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key data for purpose of CSA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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