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EC number: 273-605-2 | CAS number: 68990-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: SOP 061.00 Issue 7, Determination of Water Solubility Turbidimetric Method
- GLP compliance:
- not specified
- Other quality assurance:
- other: GMP compliance
- Type of method:
- other: turbidity method
- Specific details on test material used for the study:
- Batch number: XP3647
CAS: 68990-51-2
UVCB
White to very light yellow soft waxy solid - Key result
- Water solubility:
- 0.2 mg/L
- Conc. based on:
- not specified
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 1 h
- Temp.:
- 21 °C
- pH:
- 6.2
- Remarks on result:
- other: incubation time not specified
- Details on results:
- The water solubility was determined to be 0.2 mg/L at 21°C +/- 1°C
- Conclusions:
- The water solubility was determined to be 0.2 mg/L at 21°C +/- 1°C
- Executive summary:
The water solubility was determined using turbidity method. The water solubility was determined to be 0.2 mg/L at 21°C +/- 1°C
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Procedure based on Intertek Pharmaceutical Services Manchester SOP 55.03 Issue 9 and SOP 55.05 Issue 6
- Principles of method if other than guideline:
- Procedure based on Intertek Pharmaceutical Services Manchester SOP 55.03 Issue 9 (Surface Tension: preparation and Measurement of test Substance using the Krüss K12 Processor Tensiometer) and SOP 55.05 Issue 6 (Basic Operation of the Krüss K12 Tensiometer using Krüss Lab-Desk 2.0 Software). The sample analysis was conducted at 90% concentration according to SOP 55.03 Issue 9 section 6.33 (test substance with solubility< 1g/L)
- GLP compliance:
- not specified
- Type of method:
- other: Turbemetric method
- Specific details on test material used for the study:
- Batch number: XP3647
CAS: 68990-51-2
UVCB
White to very light yellow soft waxy solid - Key result
- Water solubility:
- >= 8.9 mg/L
- Conc. based on:
- not specified
- Loading of aqueous phase:
- 1.3 g/L
- Incubation duration:
- 1 d
- Temp.:
- 25 °C
- pH:
- ca. 7
- Remarks on result:
- other: No pH assessment of the test solutions was performed
- Conclusions:
- Water solubility < 8.9 mg/L was reported.
- Executive summary:
A mean total solubility value, calculated by addition of the water solubility values for three components determined form the surface tension analysis has been reported. This was based on a loading of 1.3g/L with an incubation period of approximately 1 day at a temperature of 25°C +/- 0.5°C. No pH assessment of the test solutions was performed.
Water solubility < 8.9 mg/L was reported.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 2018
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
- Remarks:
- please refer to summary section
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- not specified
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch number: XP3647
CAS: 68990-51-2
UVCB
White to very light yellow soft waxy solid - Conclusions:
- In summary the shake flask study applied for the test item found to be technically not feasible as it provided specific solubility results significantly in excess of the value expected from structural assessment and knowledge of the components. A further assessment of water solubility based on observations from the surface tension testing of the test item and derailed in report reference 1340388 Water solubility assessment from surface tension testing has been prepared to provide additional information. In addition determination of water solubility by turbidity was performed as a non-specific analysis to confirm the expected behavior of the test item in water using a complementary technique and detailed in report reference 1340388 Determination of the water solubility using Turbidity method
- Executive summary:
In summary the shake flask study applied for the test item found to be technically not feasible as it provided specific solubility results significantly in excess of the value expected from structural assessment and knowledge of the components. A further assessment of water solubility based on observations from the surface tension testing of the test item and derailed in report reference 1340388 Water solubility assessment from surface tension testing has been prepared to provide additional information. In addition determination of water solubility by turbidity was performed as a non-specific analysis to confirm the expected behavior of the test item in water using a complementary technique and detailed in report reference 1340388 Determination of the water solubility using Turbidity method
Referenceopen allclose all
Description of key information
The water solubility was determined using turbidity method. The water solubility was determined to be 0.2 mg/L at 21°C ±1°C
Key value for chemical safety assessment
- Water solubility:
- 0.2 mg/L
- at the temperature of:
- 21 °C
Additional information
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