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EC number: 235-043-6 | CAS number: 12060-58-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
About Samarium oxide no studies were available, but about the analogue substance Lanthanum carbonate:
Oral:
LD50 (rats) > 30404 mg/kg bw Lanthanum carbonate
Key value for chemical safety assessment
Additional information
Oral
The acute oral toxicity of Lanthanum carbonate monohydrate was tested according to the Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173 (Ward, 1976). The test substance was administered to rats in a limit test at a dose of 31600 mg/kg bw, mortality and clinical signs were observed for 48 h. Since no mortality occurred and no clinical signs were detected, the LD50 was stated as greater than 30404 mg Lanthanum carbonate/kg bw.
Furthermore, in an acute oral toxicity study according to OECD 423, a first group of 3 females was given a single oral dose of Lanthane carbonate (containing water) as such in PEG 300 at a dose of 2000 mg/kg bw and observed for 14 days (Ott, 2005). As no death and no clinical signs were observed, a second group of 3 females was tested under the same test conditions. No mortality and only minor clinical signs (slightly ruffled fur and hunched posture observed up to 3 days of the study) were observed in the second group of animals. The LD50 was stated as greater than 2000 mg/kg bw (corresponding to 1367 mg Lanthanum carbonate/kg bw).
Justification for classification or non-classification
The data on acute toxicity oral exposure are conclusive but not sufficient for classification according to the criteria of Directives 67/548/EEC (DSD) and 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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