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Diss Factsheets
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EC number: 222-429-4 | CAS number: 3468-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 February 2022 - 22 April 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- EC Number:
- 222-429-4
- EC Name:
- 1-[(2,4-dinitrophenyl)azo]-2-naphthol
- Cas Number:
- 3468-63-1
- Molecular formula:
- C16H10N4O5
- IUPAC Name:
- 1-[(2,4-dinitrophenyl)diazenyl]-2-naphthol
- Test material form:
- solid: particulate/powder
- Remarks:
- orange
Constituent 1
- Specific details on test material used for the study:
- Physical Description: Orange powder
Storage Conditions: At room temperature
Solubility in water: 6.3 μg/L
Solubility in octanol: 1.76 mg/L
Results and discussion
Water solubility
- Key result
- Water solubility:
- < 1.5 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- > 8.3 - < 8.4
- Remarks on result:
- other: average of two runs
- Details on results:
- No test material was detected at both flow rates (24 mL/h and 12 mL/h). The analyzed concentrations are, therefore, reported to be below the limit of detection (<0.76 μg/L), multiplied by the dilution factor.
Any other information on results incl. tables
- Since no test material was detected in the fraction collected from the column, column material was analyzed to demonstrate that the carrier material still contained test material after elution with water.
- No test substance was detected in the samples from the blank column.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be <1.5 μg/L.
- Executive summary:
The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.
Quantification was performed using a validated UPLC-UV method. No test material was detected at both flow rates (24 mL/h and 12 mL/h). The water solubility of the substance at 20°C was determined to be <1.5 μg/L, which was below the limit of detection of <0.76 μg/L) multiplied by the dilution factor. The pH of the aqueous samples was 8.3 and 8.4.
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