Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-926-1 | CAS number: 227605-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to internationally accepted test guidance and good laboratory practices guidance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- sodium 2-(azanidylsulfonyl)-3-(2,2,2-trifluoroethoxy)pyridine
- EC Number:
- 700-926-1
- Cas Number:
- 227605-94-9
- Molecular formula:
- C7H6F3N2NaO3S
- IUPAC Name:
- sodium 2-(azanidylsulfonyl)-3-(2,2,2-trifluoroethoxy)pyridine
- Reference substance name:
- Sodium {[3-(2,2,2-trifluoroethoxy)-2-pyridinyl]sulfonyl}azanide
- IUPAC Name:
- Sodium {[3-(2,2,2-trifluoroethoxy)-2-pyridinyl]sulfonyl}azanide
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): CA 3105 A (intermediate of CGA 362622)
- Substance type: Organic mono constituent substance
- Physical state: White solid
- Analytical purity: 93.9%
- Lot/batch No.: EZ001002
- Expiration date of the lot/batch: July 2002 (Date of re-analysis)
- Storage condition of test material: Room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Hanlbm:WIST (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd., Biotechnology & Animal Breeding Division, 4414 Füllinsdorf, Switzerland
- Age at study initiation: Young adult (approximately 8-12 weeks)
- Weight at study initiation: 202 to 249 g
- Housing: Macrolon Type 3 cages with soft wood bedding (Société Parisienne des Sciures, Patin, France); individual housing
- Diet (e.g. ad libitum): NAFAG No. 890 (NAFAG, Gossau/SG, Switzerland), available ad libitum. All batches of diet are assayed by the manufacturer to ensure proper nutritional content and absence of contaminants. A report of the assay for the diet batch used in a specific test is available.
- Water (e.g. ad libitum): Available ad libitum from bottles; source is municipal water supply. The water is examined four times a year by the government water authority (Baudepartement des Kantons Aargau, Abteilung Gewässerschutz). A report of an assay conducted about the time of the test is available on request.
- Acclimation period: At least five days before treatment.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 50% ± 20%
- Air changes (per hr): Approximately 13-14/hour
- Photoperiod (hrs dark / hrs light): 12/12 hours
IN-LIFE DATES: From: August 22, 2000 To: September 5, 2000
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 0.5% (w/v)carboxymethyl cellulose in 0.1% (w/v) aqueous polysorbate 80
- Details on dermal exposure:
- TEST SITE
- Area of exposure: An area of about 6 cm x 6 cm on the back
- % coverage: Approximately 10% of body surface
- Type of wrap if used:
Gauze patches, 6 cm x 4 cm (Rhena Gaze Kompresse, IVF, Neuhausen, Switzerland)
lsocomfort™ self-adhesive wrap (lsoplast AG, Brugg, Switzerland)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): With lukewarm water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Concentration (if solution): 10.0006 g test item moistened with 10 g vehicle
- Constant volume or concentration used: yes/no 400 mg per 100 g body weight - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical observations: Checked and recorded individually within the first two hours after dosing, then daily for the duration of the observation period.
Local tolerance: The application site was examined daily for signs of dermal irritation. Any deviations from normal were recorded using the Draize scale.
Mortality: Checked twice daily, morning and afternoon.
Body weight: Measured and recorded immediately before dose administration on days 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy observations
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortality in the study.
- Clinical signs:
- other: There were no remarkable clinical observations for any animal in either dose group.
- Gross pathology:
- Necropsy examinations revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 in male rats: Greater than 2000 mg/kg body weight
LD50 in female rats: Greater than 2000 mg/kg body weight
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight - Executive summary:
Groups of 5 male and 5 female fasted Hanlbm:WIST (SPF) rats were administered a single dose of CA 3105 A (intermediate of CGA 362622), batch no. EZ001002, by dermal application at a dose level of 2000 mg/kg for 24 hours under semiocclusive conditions, followed by a 14-day post-treatment observation period. There was no mortality. There were no remarkable clinical observations for any animal.
Very slight erythema at the skin application site was recorded in one male on days 3 and 4, in one male on day 4 only, and in two females on days 2 and 3. Well defined erythema was seen in one female on day 2 only. Crust at the application area was seen in one male on day 5 through day 12, and in one female on day 3 through day 9.
A slight loss of body weight was recorded in one female during the first week after treatment.
Necropsy examinations revealed no observable abnormalities.
The following acute dermal LD50 values were determined for CA 3105 A (intermediate of CGA 362622):
LD50 in male rats: Greater than 2000 mg/kg body weight.
LD50 in female rats: Greater than 2000 mg/kg body weight.
LD50 in rats of both sexes: Greater than 2000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.