Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: other: procedure described in paper by Ames
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary study report
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- I U C L I D D a t a s e t Substance ID: 68334–30–5
- Author:
- EUROPEAN COMMISSI – European Chemicals Bureau
- Year:
- 2 000
- Bibliographic source:
- I U C L I D D a t a s e t Substance ID: 68334–30–5 pag 671-672
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 64742–46–7
- IUPAC Name:
- 64742–46–7
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with
- Test concentrations with justification for top dose:
- 1 to 60 ul/ml of DMSO extract
Controls
- Remarks:
- No data
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
A weak mutagenic response was found, but did not vary in a dose–dependent manner. The mutagenicity index was 1.0. The authors advise that a mutagenicity index above 1.0 should be regarded as a positive response, the mutagenicity index being the slope of the dose–response curve at zero concentration.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
ambiguous
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