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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-07-03 to 1991-07-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study; well-performed and well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
sodium/triethanolamine 4-((2-hydroxyethyl)amino)-3-pentaproenyl-4-oxobutanoate
EC Number:
800-765-8
Cas Number:
1424149-03-0
Molecular formula:
C21H40NO4.1/2Na.1/2C6H15NO3
IUPAC Name:
sodium/triethanolamine 4-((2-hydroxyethyl)amino)-3-pentaproenyl-4-oxobutanoate
Details on test material:
Product No. Code: 01-FMLY 022
pH value: approx.9 (10g/L)
Content: 80% Pentapropylensuccinic anhydride, EA/Na/TEA 10% Olefin(C15-Spetapropylen), 10% Water

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Mean body weight at start of study: males 182 ± 2g, females 180 ± 4g
Age at the start of the study: males approx. 7 weeks, females approx. 8 weeks.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no effect

Any other information on results incl. tables

No mortality, no clinical sign and no body weight was observed.

The animals killed at the end of the observation period showed no macroscopically visible changes.

 

Table: Body weight development [g]

 

Day 1

Day 8

Day 15

males (n=5)

181.8± 1.5

241.4± 4.0

284.4± 6.7

females (n=5)

180.2± 4.4

203.2± 7.5

219.8± 7.8

 

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Pentapropylensuccinic anhydride, reaction products with ethanolamine, sodium and triethanolamine salts was investigated for tis acute oral toxicity according to the OECD Gudieline 401. No effect was found at the limit dose of 2000 mg/kg bw. No classification is warranted.
Executive summary:

Pentapropylensuccinic anhydride, reaction products with ethanolamine, sodium and triethanolamine salts was investigated for tis acute oral toxicity according to the OECD Gudieline 401. Five male and five female rats received Pentapropylensuccinic anhydride, reaction products with ethanolamine, sodium and triethanolamine salts as a 20% solution in water, the administration volume being 10 ml/kg body weight. No mortality, no clinical signs and no body weight effect was observed. The animals killed at the end of the observation period showed no macroscopically visible changes.

No classification is warranted.