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EC number: 249-894-6 | CAS number: 29857-13-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to GLP and valid methods. Although some details were missing, the the study is considered relevant, adequate and reliable for classification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium 1,4-diisodecyl sulphonatosuccinate
- EC Number:
- 249-894-6
- EC Name:
- Sodium 1,4-diisodecyl sulphonatosuccinate
- Cas Number:
- 29857-13-4
- IUPAC Name:
- sodium 1,4-diisodecyl sulphonatosuccinate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Netzer SB 10, sulfobernsteinsäureester-Natriumsalz, Di-isodecylsulfobernsteinsäureester-mono-natriumsalz
- Physical state: Almost colorless, clear liquid
- Analytical purity: 63.0-67.0%
- Impurities (identity and concentrations): See confidential details
- Composition of test material, percentage of components: See confidential details
- Purity test date: Not provided
- Lot/batch No.: E06 124 505 (produced 1988-07-03)
- Expiration date of the lot/batch: Not provided
- Stability under test conditions: Not provided
- Storage condition of test material: In the dark, at 22°C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Hoe:WISKf (SPF71)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, SPF
- Age at study initiation: Males ca. 7 weeks; Females ca. 8 weeks
- Weight at study initiation: 158 g mean weight males; 154 g mean weight females
- Fasting period before study: Ca. 16 hours before and 3-4 hours after application
- Housing: In groups of 5 animals, in Makrolon cages (Type 4) on softwood pellets
- Diet (e.g. ad libitum): Rattendiät Altromin 1324 (Altromin-GmbH, Lage/Lippe), ad libitum
- Water (e.g. ad libitum): Tap water in plastic bottles
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 50 ± 20%
- Air changes (per hr): Not provided
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: deionised water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% (w/v)
- Amount of vehicle (if gavage): 10 mL/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations after 10, 30 minutes, 1, 2, 4, 6 hours and then daily; weighing weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 260 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: On the day of application the animals showed nonspecific signs of toxicity. The female animals showed in addition adverse effects of the movement sequence, respiration and diarrhea. From the second day post application all the symptoms were reversible.
- Gross pathology:
- No gross pathology was observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item in male and female Wistar rats is > 2000 mg/kg bw. The test item does not require labeling according to the classification criteria of Directive 83/467/EEC and the Hazardous Substances Regulation.
- Executive summary:
Acute oral toxicity of a formulation containing 36 -67% active ingredient was tested in 10 Wistar rats (5 males and 5 females) by oral gavage of the test item in deionised water at a dose of 2000 mg/kg bw. No mortality was observed. On the day of application the animals showed nonspecific signs of toxicity. The female animals showed in addition adverse effects of the movement sequence, respiration and diarrhea. From the second day post application all the symptoms were reversible. There were no adverse effects on the bodyweight gain. No gross pathology of the euthanized animals was observed. The LD50 in male and female Wistar rats is > 2000 mg/kg bw (test material) or > 1260 mg/kg bw (active ingredient).
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